About Enhancer
| Enhancer ID: | E_02_0644 |
| Species: | human |
| Position : | chr18:63120684-63122684   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Neurodegenerative disease |
| Pubmed ID: | 31396089 |
| Enhancer experiment: | PCR, Western blot, gel electrophoresis |
| Enhancer experiment description: | Ad libitum HRW consumption also had an inhibitory effect on the METH-induced increase in the expression of Bax/Bcl-2, cleaved caspase-3, glucose-related protein 78 (GRP 78), CCAAT/enhancer-binding protein homologous protein (CHOP), and p-NF-kB p65 expression and elevation of Provisional interleukin (IL)-6 and tumor necrosis factor (TNF)-? levels in the hippocampus. |
About Target gene
| Target gene : | BCL2(Bcl-2,PPP1R50),BAX |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Ad libitum HRW consumption also had an inhibitory effect on the METH-induced increase in the expression of Bax/Bcl-2, cleaved caspase-3, glucose-related protein 78 (GRP 78), CCAAT/enhancer-binding protein homologous protein (CHOP), and p-NF-kB p65 expression and elevation of Provisional interleukin (IL)-6 and tumor necrosis factor (TNF)-? levels in the hippocampus.;Ad libitum HRW consumption also had an inhibitory effect on the METH-induced increase in the expression of Bax/Bcl-2, cleaved caspase-3, glucose-related protein 78 (GRP 78), CCAAT/enhancer-binding protein homologous protein (CHOP), and p-NF-kB p65 expression and elevation of Provisional interleukin (IL)-6 and tumor necrosis factor (TNF)-? levels in the hippocampus. |
About TF
| TF name : | -- |
| TF experiment: | PCR,Western blot,???? |
| TF experiment description: | Ad libitum HRW consumption also had an inhibitory effect on the METH-induced increase in the expression of Bax/Bcl-2, cleaved caspase-3, glucose-related protein 78 (GRP 78), CCAAT/enhancer-binding protein homologous protein (CHOP), and p-NF-kB p65 expression and elevation of Provisional interleukin (IL)-6 and tumor necrosis factor (TNF)-? levels in the hippocampus.;Ad libitum HRW consumption also had an inhibitory effect on the METH-induced increase in the expression of Bax/Bcl-2, cleaved caspase-3, glucose-related protein 78 (GRP 78), CCAAT/enhancer-binding protein homologous protein (CHOP), and p-NF-kB p65 expression and elevation of Provisional interleukin (IL)-6 and tumor necrosis factor (TNF)-? levels in the hippocampus. |
About Function
| Enhancer function : | Ad libitum HRW consumption also had an inhibitory effect on the METH-induced increase in the expression of Bax/Bcl-2, cleaved caspase-3, glucose-related protein 78 (GRP 78), CCAAT/enhancer-binding protein homologous protein (CHOP), and p-NF-kB p65 expression and elevation of Provisional interleukin (IL)-6 and tumor necrosis factor (TNF)-? levels in the hippocampus. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Ad libitum HRW consumption also had an inhibitory effect on the METH-induced increase in the expression of Bax/Bcl-2, cleaved caspase-3, glucose-related protein 78 (GRP 78), CCAAT/enhancer-binding protein homologous protein (CHOP), and p-NF-kB p65 expression and elevation of Provisional interleukin (IL)-6 and tumor necrosis factor (TNF)-? levels in the hippocampus. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene