About Enhancer
| Enhancer ID: | E_02_0636 |
| Species: | human |
| Position : | chr8:132864337-132866337   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Metabolic disease (metabolic disease) |
| Pubmed ID: | 31406023 |
| Enhancer experiment: | PCR, Western blot, gel electrophoresis |
| Enhancer experiment description: | Moreover, inhibition of ER stress by 4-phenylbutyrate (4-PBA) attenuated thapsigargin-(TG, ER stress agonist) or LPS-induced reduction of Cyp19al and E2, pro-inflammatory cytokines expression (IL-1?, IL-6, IL-8, and TNF-a), and the expression of CHOP and GRP78. |
About Target gene
| Target gene : | TG |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Moreover, inhibition of ER stress by 4-phenylbutyrate (4-PBA) attenuated thapsigargin-(TG, ER stress agonist) or LPS-induced reduction of Cyp19al and E2, pro-inflammatory cytokines expression (IL-1?, IL-6, IL-8, and TNF-a), and the expression of CHOP and GRP78. |
About TF
| TF name : | -- |
| TF experiment: | PCR,Western blot,???? |
| TF experiment description: | Moreover, inhibition of ER stress by 4-phenylbutyrate (4-PBA) attenuated thapsigargin-(TG, ER stress agonist) or LPS-induced reduction of Cyp19al and E2, pro-inflammatory cytokines expression (IL-1?, IL-6, IL-8, and TNF-a), and the expression of CHOP and GRP78. |
About Function
| Enhancer function : | Moreover, inhibition of ER stress by 4-phenylbutyrate (4-PBA) attenuated thapsigargin-(TG, ER stress agonist) or LPS-induced reduction of Cyp19al and E2, pro-inflammatory cytokines expression (IL-1?, IL-6, IL-8, and TNF-a), and the expression of CHOP and GRP78. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Moreover, inhibition of ER stress by 4-phenylbutyrate (4-PBA) attenuated thapsigargin-(TG, ER stress agonist) or LPS-induced reduction of Cyp19al and E2, pro-inflammatory cytokines expression (IL-1?, IL-6, IL-8, and TNF-a), and the expression of CHOP and GRP78. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene