About Enhancer
| Enhancer ID: |
E_02_0605 |
| Species: |
human |
| Position :
|
chr3:51382539-51384539
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Alzheimer's disease |
| Pubmed ID: |
31469428
|
| Enhancer experiment: |
PCR, Western blot, gene knockdown, gel electrophoresis |
| Enhancer experiment description: |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER stress-inducible secretion protein that inhibits inflammation by interacting with the key subunit of nuclear factor kappa light chain enhancer of acti_x005f_x0002_vated B cells (NF-?B) p65. |
About Target gene
| Target gene : |
MANF |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER stress-inducible secretion protein that inhibits inflammation by interacting with the key subunit of nuclear factor kappa light chain enhancer of acti_x005f_x0002_vated B cells (NF-?B) p65. |
About TF
| TF name : |
-- |
| TF experiment: |
PCR,Western blot,????,???? |
| TF experiment description: |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER stress-inducible secretion protein that inhibits inflammation by interacting with the key subunit of nuclear factor kappa light chain enhancer of acti_x005f_x0002_vated B cells (NF-?B) p65. |
About Function
| Enhancer function : |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER stress-inducible secretion protein that inhibits inflammation by interacting with the key subunit of nuclear factor kappa light chain enhancer of acti_x005f_x0002_vated B cells (NF-?B) p65. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER stress-inducible secretion protein that inhibits inflammation by interacting with the key subunit of nuclear factor kappa light chain enhancer of acti_x005f_x0002_vated B cells (NF-?B) p65. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs