About Enhancer
| Enhancer ID: | E_02_0602 |
| Species: | human |
| Position : | chr13:73052160-73054160   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 33078455 |
| Enhancer experiment: | RNA isolation and quantitative real_x0002_time PCR (qRT-PCR)?Luciferase reporter assay?20S proteasome activity assay |
| Enhancer experiment description: | These results suggest that CLU is a novel regulator of adipocyte differentiation by modulating the protein stability of the adipogenic transcription factor KLF5. |
About Target gene
| Target gene : | KLF5(BTEB2,CKLF,IKLF),CLU(AAG4,APO-J,APOJ,CLI,CLU1,CLU2,KUB1,NA1/NA2,SGP-2,SGP2,SP-40,TRPM-2,TRPM2),Cebpa(C/ebpalpha,CBF-A,Cebp),Pparg(Nr1c3,PPAR-gamma,PPAR-gamma2,PPARgamma,PPARgamma2) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | These results suggest that CLU is a novel regulator of adipocyte differentiation by modulating the protein stability of the adipogenic transcription factor KLF5.;CLU overexpression promoted adipogenic differentiation of preadipocytes and increased the mRNA levels of adipogenic markers including peroxisome proliferator-activated receptor ? (Pparg) and CCAAT enhancer-binding protein ? (Cebpa).;CLU overexpression promoted adipogenic differentiation of preadipocytes and increased the mRNA levels of adipogenic markers including peroxisome proliferator-activated receptor ? (Pparg) and CCAAT enhancer-binding protein ? (Cebpa).;CLU overexpression promoted adipogenic differentiation of preadipocytes and increased the mRNA levels of adipogenic markers including peroxisome proliferator-activated receptor ? (Pparg) and CCAAT enhancer-binding protein ? (Cebpa). |
About TF
| TF name : | -- |
| TF experiment: | RNA isolation and quantitative real_x0002_time PCR (qRT-PCR)?Luciferase reporter assay?20S proteasome activity assay |
| TF experiment description: | These results suggest that CLU is a novel regulator of adipocyte differentiation by modulating the protein stability of the adipogenic transcription factor KLF5.;CLU overexpression promoted adipogenic differentiation of preadipocytes and increased the mRNA levels of adipogenic markers including peroxisome proliferator-activated receptor ? (Pparg) and CCAAT enhancer-binding protein ? (Cebpa).;CLU overexpression promoted adipogenic differentiation of preadipocytes and increased the mRNA levels of adipogenic markers including peroxisome proliferator-activated receptor ? (Pparg) and CCAAT enhancer-binding protein ? (Cebpa).;CLU overexpression promoted adipogenic differentiation of preadipocytes and increased the mRNA levels of adipogenic markers including peroxisome proliferator-activated receptor ? (Pparg) and CCAAT enhancer-binding protein ? (Cebpa). |
About Function
| Enhancer function : | These results suggest that CLU is a novel regulator of adipocyte differentiation by modulating the protein stability of the adipogenic transcription factor KLF5. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
These results suggest that CLU is a novel regulator of adipocyte differentiation by modulating the protein stability of the adipogenic transcription factor KLF5. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene