About Enhancer
| Enhancer ID: |
E_02_0601 |
| Species: |
mouse |
| Position :
|
chr17:27055027-27057027
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Heart failure |
| Pubmed ID: |
33083767
|
| Enhancer experiment: |
RNA sequencing (RNA SEQ), quantitative PCR (qPCR), cell fractionation, rna-fish, Western blotting, fluorescent immunoassay |
| Enhancer experiment description: |
We have identified an autoregulatory loop controlling expression of the master cardiac TF NKX2-5, in which one eRNA represses transcription. |
About Target gene
| Target gene : |
Nkx2-5(CHNG5,CSX,CSX1,HLHS2,NKX2.5,NKX2E,NKX4-1,VSD3) |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
We have identified an autoregulatory loop controlling expression of the master cardiac TF NKX2-5, in which one eRNA represses transcription. |
About TF
| TF name : |
-- |
| TF experiment: |
RNA???RNA-seq????PCR?qPCR???????RNA-FISH????????????? |
| TF experiment description: |
We have identified an autoregulatory loop controlling expression of the master cardiac TF NKX2-5, in which one eRNA represses transcription. |
About Function
| Enhancer function : |
We have identified an autoregulatory loop controlling expression of the master cardiac TF NKX2-5, in which one eRNA represses transcription. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
We have identified an autoregulatory loop controlling expression of the master cardiac TF NKX2-5, in which one eRNA represses transcription. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs