About Enhancer
| Enhancer ID: | E_02_0593 |
| Species: | human |
| Position : | chr10:13096741-13098741   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Senile osteoporosis |
| Pubmed ID: | 33143524 |
| Enhancer experiment: | Three point bending test, LC-MS analysis and data analysis, ROS detection, QRT PCR, enzyme-linked immunosorbent assay (ELISA), sa-glb1 staining. Histochemical and immunohistochemical staining, Western blot analysis, CO immunoprecipitation analysis |
| Enhancer experiment description: | OPTN (optineurin), a macroautophagy/autophagy (hereinafter referred to as autophagy) receptor, is found to play a pivotal role in selective autophagy, coupling autophagy with bone metabolism. However, its role in osteogenesis is still mysterious. |
About Target gene
| Target gene : | OPTN |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | OPTN (optineurin), a macroautophagy/autophagy (hereinafter referred to as autophagy) receptor, is found to play a pivotal role in selective autophagy, coupling autophagy with bone metabolism. However, its role in osteogenesis is still mysterious. |
About TF
| TF name : | -- |
| TF experiment: | ???????LC-MS ????????ROS ???qRT-PCR????????? ?ELISA??SA-GLB1 ??????????????????????????????? |
| TF experiment description: | OPTN (optineurin), a macroautophagy/autophagy (hereinafter referred to as autophagy) receptor, is found to play a pivotal role in selective autophagy, coupling autophagy with bone metabolism. However, its role in osteogenesis is still mysterious. |
About Function
| Enhancer function : | OPTN (optineurin), a macroautophagy/autophagy (hereinafter referred to as autophagy) receptor, is found to play a pivotal role in selective autophagy, coupling autophagy with bone metabolism. However, its role in osteogenesis is still mysterious. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
OPTN (optineurin), a macroautophagy/autophagy (hereinafter referred to as autophagy) receptor, is found to play a pivotal role in selective autophagy, coupling autophagy with bone metabolism. However, its role in osteogenesis is still mysterious. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene