About Enhancer
| Enhancer ID: |
E_02_0592 |
| Species: |
mouse |
| Position :
|
chr18:38066305-38068305
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Bronchial dysplasia |
| Pubmed ID: |
33143661
|
| Enhancer experiment: |
Immunohistochemistry, immunofluorescence staining of microvessel density (MVD), RNA extraction and gene expression extraction, Western blot analysis, chromatin immunoprecipitation (chip) assay |
| Enhancer experiment description: |
The present study revealed that Hdac3 activated the EZH1-p65-Pgf axis through inhibiting miR-17 in the miR-17-92 cluster, leading to accelerated abnormal pulmonary angiogenesis and alveolarization of BPD mice. |
About Target gene
| Target gene : |
Hdac3 |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
The present study revealed that Hdac3 activated the EZH1-p65-Pgf axis through inhibiting miR-17 in the miR-17-92 cluster, leading to accelerated abnormal pulmonary angiogenesis and alveolarization of BPD mice. |
About TF
| TF name : |
-- |
| TF experiment: |
???????????MVD?????????RNA??????????????????????????ChIP??? |
| TF experiment description: |
The present study revealed that Hdac3 activated the EZH1-p65-Pgf axis through inhibiting miR-17 in the miR-17-92 cluster, leading to accelerated abnormal pulmonary angiogenesis and alveolarization of BPD mice. |
About Function
| Enhancer function : |
The present study revealed that Hdac3 activated the EZH1-p65-Pgf axis through inhibiting miR-17 in the miR-17-92 cluster, leading to accelerated abnormal pulmonary angiogenesis and alveolarization of BPD mice. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
The present study revealed that Hdac3 activated the EZH1-p65-Pgf axis through inhibiting miR-17 in the miR-17-92 cluster, leading to accelerated abnormal pulmonary angiogenesis and alveolarization of BPD mice. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs