About Enhancer
| Enhancer ID: | E_02_0584 |
| Species: | human |
| Position : | chr4:108044684-108046684   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Parkinson's disease |
| Pubmed ID: | 33195246 |
| Enhancer experiment: | Microarray analysis, immunohistochemistry / immunocytochemistry, VM primary cultures and rspo2 / edu treatment, Western blotting, chromatin immunoprecipitation polymerase chain reaction, transfection, luciferase reporter assays and site directed mutagenesis, fast polymerase chain reaction |
| Enhancer experiment description: | This effect is mediated by RSPO2, a WNT/b-catenin agonist, and lymphoid enhancer binding factor 1 (LEF1), an essential nuclear effector of the WNT/b-catenin pathway, via conserved LEF1/T-cell factor binding sites in the Pitx3 promoter. |
About Target gene
| Target gene : | LEF1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | This effect is mediated by RSPO2, a WNT/b-catenin agonist, and lymphoid enhancer binding factor 1 (LEF1), an essential nuclear effector of the WNT/b-catenin pathway, via conserved LEF1/T-cell factor binding sites in the Pitx3 promoter. |
About TF
| TF name : | -- |
| TF experiment: | ??????????/???????VM ????? RSPO2/EdU ????????????????-???????????????????????????????? |
| TF experiment description: | This effect is mediated by RSPO2, a WNT/b-catenin agonist, and lymphoid enhancer binding factor 1 (LEF1), an essential nuclear effector of the WNT/b-catenin pathway, via conserved LEF1/T-cell factor binding sites in the Pitx3 promoter. |
About Function
| Enhancer function : | This effect is mediated by RSPO2, a WNT/b-catenin agonist, and lymphoid enhancer binding factor 1 (LEF1), an essential nuclear effector of the WNT/b-catenin pathway, via conserved LEF1/T-cell factor binding sites in the Pitx3 promoter. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
This effect is mediated by RSPO2, a WNT/b-catenin agonist, and lymphoid enhancer binding factor 1 (LEF1), an essential nuclear effector of the WNT/b-catenin pathway, via conserved LEF1/T-cell factor binding sites in the Pitx3 promoter. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene