About Enhancer
| Enhancer ID: | E_02_0582 |
| Species: | human |
| Position : | chr14:24332849-24334849   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Atherosclerosis |
| Pubmed ID: | 33222501 |
| Enhancer experiment: | Western blot, cell viability assay, NF- ? B luciferase assay, immunofluorescence of HUVECs |
| Enhancer experiment description: | Upstream of the RIPK3-MLKL necroptotic machinery lies RIPK1 (receptor-interacting serine/threonine-protein kinase 1), which acts as a master switch that controls whether the cell undergoes NF-?B (nuclear factor ?-light-chain-enhancer of activated B cells)dependent inflammation, caspase-dependent apoptosis, or necroptosis in response to extracellular stimuli. |
About Target gene
| Target gene : | RIPK3 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Upstream of the RIPK3-MLKL necroptotic machinery lies RIPK1 (receptor-interacting serine/threonine-protein kinase 1), which acts as a master switch that controls whether the cell undergoes NF-?B (nuclear factor ?-light-chain-enhancer of activated B cells)dependent inflammation, caspase-dependent apoptosis, or necroptosis in response to extracellular stimuli. |
About TF
| TF name : | -- |
| TF experiment: | ?????????????NF-?B???????HUVECs????? |
| TF experiment description: | Upstream of the RIPK3-MLKL necroptotic machinery lies RIPK1 (receptor-interacting serine/threonine-protein kinase 1), which acts as a master switch that controls whether the cell undergoes NF-?B (nuclear factor ?-light-chain-enhancer of activated B cells)dependent inflammation, caspase-dependent apoptosis, or necroptosis in response to extracellular stimuli. |
About Function
| Enhancer function : | Upstream of the RIPK3-MLKL necroptotic machinery lies RIPK1 (receptor-interacting serine/threonine-protein kinase 1), which acts as a master switch that controls whether the cell undergoes NF-?B (nuclear factor ?-light-chain-enhancer of activated B cells)dependent inflammation, caspase-dependent apoptosis, or necroptosis in response to extracellular stimuli. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Upstream of the RIPK3-MLKL necroptotic machinery lies RIPK1 (receptor-interacting serine/threonine-protein kinase 1), which acts as a master switch that controls whether the cell undergoes NF-?B (nuclear factor ?-light-chain-enhancer of activated B cells)dependent inflammation, caspase-dependent apoptosis, or necroptosis in response to extracellular stimuli. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene