About Enhancer
| Enhancer ID: | E_02_0544 |
| Species: | human |
| Position : | chr4:140556428-140558428   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Type 2 diabetes, obesity |
| Pubmed ID: | 29966981 |
| Enhancer experiment: | Real time PCR, Western blot, and statistical analysis |
| Enhancer experiment description: | Furthermore, PME supplementation significantly up-regulated the PPAR?, CPT1, CPT2, UCP1 and HSL mRNA levels compared with the HFD group, whereas it down-regulated expression of the PPAR? and DGAT2 genes. |
About Target gene
| Target gene : | UCP1(AI385626,Slc25a7,Ucp),CPT2,DGAT2 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Furthermore, PME supplementation significantly up-regulated the PPAR?, CPT1, CPT2, UCP1 and HSL mRNA levels compared with the HFD group, whereas it down-regulated expression of the PPAR? and DGAT2 genes.;Furthermore, PME supplementation significantly up-regulated the PPAR?, CPT1, CPT2, UCP1 and HSL mRNA levels compared with the HFD group, whereas it down-regulated expression of the PPAR? and DGAT2 genes.;Furthermore, PME supplementation significantly up-regulated the PPAR?, CPT1, CPT2, UCP1 and HSL mRNA levels compared with the HFD group, whereas it down-regulated expression of the PPAR? and DGAT2 genes. |
About TF
| TF name : | -- |
| TF experiment: | real-time PCR,Western blot,???? |
| TF experiment description: | Furthermore, PME supplementation significantly up-regulated the PPAR?, CPT1, CPT2, UCP1 and HSL mRNA levels compared with the HFD group, whereas it down-regulated expression of the PPAR? and DGAT2 genes.;Furthermore, PME supplementation significantly up-regulated the PPAR?, CPT1, CPT2, UCP1 and HSL mRNA levels compared with the HFD group, whereas it down-regulated expression of the PPAR? and DGAT2 genes.;Furthermore, PME supplementation significantly up-regulated the PPAR?, CPT1, CPT2, UCP1 and HSL mRNA levels compared with the HFD group, whereas it down-regulated expression of the PPAR? and DGAT2 genes. |
About Function
| Enhancer function : | Furthermore, PME supplementation significantly up-regulated the PPAR?, CPT1, CPT2, UCP1 and HSL mRNA levels compared with the HFD group, whereas it down-regulated expression of the PPAR? and DGAT2 genes. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Furthermore, PME supplementation significantly up-regulated the PPAR?, CPT1, CPT2, UCP1 and HSL mRNA levels compared with the HFD group, whereas it down-regulated expression of the PPAR? and DGAT2 genes. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene