About Enhancer
| Enhancer ID: | E_02_0528 |
| Species: | human |
| Position : | chr7:96478877-96480877   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Hiv |
| Pubmed ID: | 30012153 |
| Enhancer experiment: | MTT assay, WB assay, SPR analysis, flow cytometry, statistical analysis, immunofluorescence staining |
| Enhancer experiment description: | Some other endogenous amyloid aggregates that increase HIV-1 infectivity, including the PAP N-proximal fragment (PAP85 120) and semenogelins (SEM1 and SEM2), have been identified in human semen [7, 8], which may explain the discrepancy between the low infectiousness of HIV in vitro and its observed efficient sexual transmission. |
About Target gene
| Target gene : | SEM1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Some other endogenous amyloid aggregates that increase HIV-1 infectivity, including the PAP N-proximal fragment (PAP85 120) and semenogelins (SEM1 and SEM2), have been identified in human semen [7, 8], which may explain the discrepancy between the low infectiousness of HIV in vitro and its observed efficient sexual transmission. |
About TF
| TF name : | -- |
| TF experiment: | MTT?,WB assay,,SPR analysis,?????,????,?????? |
| TF experiment description: | Some other endogenous amyloid aggregates that increase HIV-1 infectivity, including the PAP N-proximal fragment (PAP85 120) and semenogelins (SEM1 and SEM2), have been identified in human semen [7, 8], which may explain the discrepancy between the low infectiousness of HIV in vitro and its observed efficient sexual transmission. |
About Function
| Enhancer function : | Some other endogenous amyloid aggregates that increase HIV-1 infectivity, including the PAP N-proximal fragment (PAP85 120) and semenogelins (SEM1 and SEM2), have been identified in human semen [7, 8], which may explain the discrepancy between the low infectiousness of HIV in vitro and its observed efficient sexual transmission. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Some other endogenous amyloid aggregates that increase HIV-1 infectivity, including the PAP N-proximal fragment (PAP85 120) and semenogelins (SEM1 and SEM2), have been identified in human semen [7, 8], which may explain the discrepancy between the low infectiousness of HIV in vitro and its observed efficient sexual transmission. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene