About Enhancer
| Enhancer ID: | E_02_0526 |
| Species: | human |
| Position : | chr16:69184468-69186468   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Inflammation |
| Pubmed ID: | 30014220 |
| Enhancer experiment: | Western blot, immunofluorescence staining, gene knockdown |
| Enhancer experiment description: | The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. In vitro data suppose a function of the syntrophins in stabilizing ATP-binding cassette transporter A1 (ABCA1), a major regulator of serum cholesterol levels [8]. |
About Target gene
| Target gene : | SNTB2,ABCA1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. In vitro data suppose a function of the syntrophins in stabilizing ATP-binding cassette transporter A1 (ABCA1), a major regulator of serum cholesterol levels [8].;The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. In vitro data suppose a function of the syntrophins in stabilizing ATP-binding cassette transporter A1 (ABCA1), a major regulator of serum cholesterol levels [8]. |
About TF
| TF name : | -- |
| TF experiment: | western blot,??????,???? |
| TF experiment description: | The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. In vitro data suppose a function of the syntrophins in stabilizing ATP-binding cassette transporter A1 (ABCA1), a major regulator of serum cholesterol levels [8].;The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. In vitro data suppose a function of the syntrophins in stabilizing ATP-binding cassette transporter A1 (ABCA1), a major regulator of serum cholesterol levels [8]. |
About Function
| Enhancer function : | The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. In vitro data suppose a function of the syntrophins in stabilizing ATP-binding cassette transporter A1 (ABCA1), a major regulator of serum cholesterol levels [8]. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
The scaffold protein beta 2 syntrophin (SNTB2) controls signaling events by recruiting distinct membrane and cytoskeletal proteins, and binds to utrophin. In vitro data suppose a function of the syntrophins in stabilizing ATP-binding cassette transporter A1 (ABCA1), a major regulator of serum cholesterol levels [8]. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene