About Enhancer
| Enhancer ID: | E_02_0522 |
| Species: | human |
| Position : | chr4:26160604-26162604   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Malignancy |
| Pubmed ID: | 30021904 |
| Enhancer experiment: | SDS-PAGE and Western blotting,ChIP-QPCR,RT-QPCR,western blot |
| Enhancer experiment description: | We demonstrate that EBNA2 can activate IRF4 and miR-155HG expression through specific upstream enhancers that are dependent on the Notch signaling transcription factor RBPJ, a known binding partner of EBNA2. |
About Target gene
| Target gene : | RBPJ(AOS3,CBF1,IGKJRB,IGKJRB1,KBF2,RBP-JK,RBPSUH,SUH,csl,RBPJ) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | We demonstrate that EBNA2 can activate IRF4 and miR-155HG expression through specific upstream enhancers that are dependent on the Notch signaling transcription factor RBPJ, a known binding partner of EBNA2. |
About TF
| TF name : | -- |
| TF experiment: | SDS-PAGE and Western blotting,ChIP-QPCR,RT-QPCR,western blot |
| TF experiment description: | We demonstrate that EBNA2 can activate IRF4 and miR-155HG expression through specific upstream enhancers that are dependent on the Notch signaling transcription factor RBPJ, a known binding partner of EBNA2. |
About Function
| Enhancer function : | We demonstrate that EBNA2 can activate IRF4 and miR-155HG expression through specific upstream enhancers that are dependent on the Notch signaling transcription factor RBPJ, a known binding partner of EBNA2. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
We demonstrate that EBNA2 can activate IRF4 and miR-155HG expression through specific upstream enhancers that are dependent on the Notch signaling transcription factor RBPJ, a known binding partner of EBNA2. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene