About Enhancer
| Enhancer ID: | E_02_0517 |
| Species: | human |
| Position : | chr8:66917733-66919733   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Gastric cancer |
| Pubmed ID: | 30031062 |
| Enhancer experiment: | QRT PCR, immunohistochemical staining, Western blot, rna-fish, statistical analysis |
| Enhancer experiment description: | Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6]. |
About Target gene
| Target gene : | SNHG6,EZH2,H19,XIST |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6].;Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6].;Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6].;Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6]. |
About TF
| TF name : | -- |
| TF experiment: | qRT-PCR,Immunohistochemical staining,western blot,RNA-FISH,???? |
| TF experiment description: | Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6].;Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6].;Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6].;Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6]. |
About Function
| Enhancer function : | Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6]. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Small nucleolar RNA host gene 6 (SNHG6) plays a role in the progression of human cancers. Furthermore, the activation of the c-Jun N-terminal kinase (JNK) pathway and the decrease in Enhancer of Zeste Homolog 2 (EZH2) expression levels represented two mutually independent mechanisms by which SNHG6 knockdown resulted in the upregulation of p21. H19 and XIST, the first two non-coding RNAs (ncRNAs), are found to lack large open reading frames and the capability to produce identifiable protein products [4-6]. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene