About Enhancer
| Enhancer ID: | E_02_0515 |
| Species: | human |
| Position : | chr8:11673642-11675642   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 30035248 |
| Enhancer experiment: | Immunohistochemistry, RNA in situ (rnascope), quantitative PCR, statistical analysis |
| Enhancer experiment description: | GATA4 is a zinc finger transcription factor that is a pioneer factor in various tissues and regulates tissue specific gene regulation. To determine if Runx2 is a direct target of GATA4, chromatin immunoprecipitation (ChIP) was performed, and it demonstrated that GATA4 is recruited to the two Runx2 promoters and an enhancer region. |
About Target gene
| Target gene : | GATA4(Gata-4),Runx2(AML3,CBF-alpha-1,CBFA1,CCD,CCD1,CLCD,OSF-2,OSF2,PEA2aA,PEBP2aA) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | GATA4 is a zinc finger transcription factor that is a pioneer factor in various tissues and regulates tissue specific gene regulation. To determine if Runx2 is a direct target of GATA4, chromatin immunoprecipitation (ChIP) was performed, and it demonstrated that GATA4 is recruited to the two Runx2 promoters and an enhancer region. ;GATA4 is a zinc finger transcription factor that is a pioneer factor in various tissues and regulates tissue specific gene regulation. To determine if Runx2 is a direct target of GATA4, chromatin immunoprecipitation (ChIP) was performed, and it demonstrated that GATA4 is recruited to the two Runx2 promoters and an enhancer region. |
About TF
| TF name : | -- |
| TF experiment: | Immunohistochemistry,RNA in situ (RNAscope),Quantitative PCR,???? |
| TF experiment description: | GATA4 is a zinc finger transcription factor that is a pioneer factor in various tissues and regulates tissue specific gene regulation. To determine if Runx2 is a direct target of GATA4, chromatin immunoprecipitation (ChIP) was performed, and it demonstrated that GATA4 is recruited to the two Runx2 promoters and an enhancer region. ;GATA4 is a zinc finger transcription factor that is a pioneer factor in various tissues and regulates tissue specific gene regulation. To determine if Runx2 is a direct target of GATA4, chromatin immunoprecipitation (ChIP) was performed, and it demonstrated that GATA4 is recruited to the two Runx2 promoters and an enhancer region. |
About Function
| Enhancer function : | GATA4 is a zinc finger transcription factor that is a pioneer factor in various tissues and regulates tissue specific gene regulation. To determine if Runx2 is a direct target of GATA4, chromatin immunoprecipitation (ChIP) was performed, and it demonstrated that GATA4 is recruited to the two Runx2 promoters and an enhancer region. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
GATA4 is a zinc finger transcription factor that is a pioneer factor in various tissues and regulates tissue specific gene regulation. To determine if Runx2 is a direct target of GATA4, chromatin immunoprecipitation (ChIP) was performed, and it demonstrated that GATA4 is recruited to the two Runx2 promoters and an enhancer region. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene