About Enhancer
| Enhancer ID: | E_02_0510 |
| Species: | human |
| Position : | chr2:135836643-135838643   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Obesity, osteoporosis |
| Pubmed ID: | 30044535 |
| Enhancer experiment: | Western blot,Q?PCR |
| Enhancer experiment description: | Examples of the former include fruitful investigations of how specific enhancers underlie phenotypic changes, e.g. cis-regulatory changes of the yellow locus affecting Drosophila pigmentation [10, 11], recurrent deletions of a Pitx1 enhancer resulting in the loss of pelvic armor in stickleback [12], and recurrent SNPs in the intron of MCM6, resulting in lactase persistence in humans [13, 14]. |
About Target gene
| Target gene : | MCM6(MCG40308,Mis5,P105MCM) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Examples of the former include fruitful investigations of how specific enhancers underlie phenotypic changes, e.g. cis-regulatory changes of the yellow locus affecting Drosophila pigmentation [10, 11], recurrent deletions of a Pitx1 enhancer resulting in the loss of pelvic armor in stickleback [12], and recurrent SNPs in the intron of MCM6, resulting in lactase persistence in humans [13, 14]. |
About TF
| TF name : | -- |
| TF experiment: | Western blot,Q?PCR |
| TF experiment description: | Examples of the former include fruitful investigations of how specific enhancers underlie phenotypic changes, e.g. cis-regulatory changes of the yellow locus affecting Drosophila pigmentation [10, 11], recurrent deletions of a Pitx1 enhancer resulting in the loss of pelvic armor in stickleback [12], and recurrent SNPs in the intron of MCM6, resulting in lactase persistence in humans [13, 14]. |
About Function
| Enhancer function : | Examples of the former include fruitful investigations of how specific enhancers underlie phenotypic changes, e.g. cis-regulatory changes of the yellow locus affecting Drosophila pigmentation [10, 11], recurrent deletions of a Pitx1 enhancer resulting in the loss of pelvic armor in stickleback [12], and recurrent SNPs in the intron of MCM6, resulting in lactase persistence in humans [13, 14]. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Examples of the former include fruitful investigations of how specific enhancers underlie phenotypic changes, e.g. cis-regulatory changes of the yellow locus affecting Drosophila pigmentation [10, 11], recurrent deletions of a Pitx1 enhancer resulting in the loss of pelvic armor in stickleback [12], and recurrent SNPs in the intron of MCM6, resulting in lactase persistence in humans [13, 14]. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene