About Enhancer
| Enhancer ID: | E_02_0504 |
| Species: | human |
| Position : | chr1:212683365-212685365   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Adult t cell leukemia / lymphoma (atll) |
| Pubmed ID: | 30057145 |
| Enhancer experiment: | Q-RT-PCR, chip SEQ, crispr-cas9 screening, immunoblot analysis, Western blot |
| Enhancer experiment description: | RNAi screening of ATLL lines revealed that their proliferation depends on BATF3 and IRF4, which cooperatively drive ATLL-specific gene expression. |
About Target gene
| Target gene : | BATF3,MYC(MRTLC,bHLHe39,c-Myc) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | RNAi screening of ATLL lines revealed that their proliferation depends on BATF3 and IRF4, which cooperatively drive ATLL-specific gene expression.;RNAi screening of ATLL lines revealed that their proliferation depends on BATF3 and IRF4, which cooperatively drive ATLL-specific gene expression. |
About TF
| TF name : | -- |
| TF experiment: | Q-RT-PCR,ChIP-seq,CRISPR-Cas9??,Immunoblot Analysis,western blot |
| TF experiment description: | RNAi screening of ATLL lines revealed that their proliferation depends on BATF3 and IRF4, which cooperatively drive ATLL-specific gene expression.;RNAi screening of ATLL lines revealed that their proliferation depends on BATF3 and IRF4, which cooperatively drive ATLL-specific gene expression. |
About Function
| Enhancer function : | RNAi screening of ATLL lines revealed that their proliferation depends on BATF3 and IRF4, which cooperatively drive ATLL-specific gene expression. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
RNAi screening of ATLL lines revealed that their proliferation depends on BATF3 and IRF4, which cooperatively drive ATLL-specific gene expression. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene