About Enhancer
| Enhancer ID: | E_02_0496 |
| Species: | human |
| Position : | chr8:63165731-63167731   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Hepatocellular carcinoma |
| Pubmed ID: | 30080426 |
| Enhancer experiment: | QRT-PCR, statistical analysis |
| Enhancer experiment description: | Recently, it was reported that m6A motif was sufficient to drive translation initiation in circRNAs; and m6A motif-driven translation required eukaryotic translation initiation factor 4 gamma 2 (eIF4G2) and m6A reader YTH domain family protein 3 (YTHDF3) in human cells [21]. Myh is divided into different subtypes, and Myh1 is the signature gene of fast-twitch muscle fibers [26], while Myh7 is important for slow-twitch muscle fibers [27]. |
About Target gene
| Target gene : | YTHDF3,Myh1,Myh7 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Recently, it was reported that m6A motif was sufficient to drive translation initiation in circRNAs; and m6A motif-driven translation required eukaryotic translation initiation factor 4 gamma 2 (eIF4G2) and m6A reader YTH domain family protein 3 (YTHDF3) in human cells [21]. Myh is divided into different subtypes, and Myh1 is the signature gene of fast-twitch muscle fibers [26], while Myh7 is important for slow-twitch muscle fibers [27]. ;Recently, it was reported that m6A motif was sufficient to drive translation initiation in circRNAs; and m6A motif-driven translation required eukaryotic translation initiation factor 4 gamma 2 (eIF4G2) and m6A reader YTH domain family protein 3 (YTHDF3) in human cells [21]. Myh is divided into different subtypes, and Myh1 is the signature gene of fast-twitch muscle fibers [26], while Myh7 is important for slow-twitch muscle fibers [27]. ;Recently, it was reported that m6A motif was sufficient to drive translation initiation in circRNAs; and m6A motif-driven translation required eukaryotic translation initiation factor 4 gamma 2 (eIF4G2) and m6A reader YTH domain family protein 3 (YTHDF3) in human cells [21]. Myh is divided into different subtypes, and Myh1 is the signature gene of fast-twitch muscle fibers [26], while Myh7 is important for slow-twitch muscle fibers [27]. |
About TF
| TF name : | -- |
| TF experiment: | QRT-PCR,???? |
| TF experiment description: | Recently, it was reported that m6A motif was sufficient to drive translation initiation in circRNAs; and m6A motif-driven translation required eukaryotic translation initiation factor 4 gamma 2 (eIF4G2) and m6A reader YTH domain family protein 3 (YTHDF3) in human cells [21]. Myh is divided into different subtypes, and Myh1 is the signature gene of fast-twitch muscle fibers [26], while Myh7 is important for slow-twitch muscle fibers [27]. ;Recently, it was reported that m6A motif was sufficient to drive translation initiation in circRNAs; and m6A motif-driven translation required eukaryotic translation initiation factor 4 gamma 2 (eIF4G2) and m6A reader YTH domain family protein 3 (YTHDF3) in human cells [21]. Myh is divided into different subtypes, and Myh1 is the signature gene of fast-twitch muscle fibers [26], while Myh7 is important for slow-twitch muscle fibers [27]. ;Recently, it was reported that m6A motif was sufficient to drive translation initiation in circRNAs; and m6A motif-driven translation required eukaryotic translation initiation factor 4 gamma 2 (eIF4G2) and m6A reader YTH domain family protein 3 (YTHDF3) in human cells [21]. Myh is divided into different subtypes, and Myh1 is the signature gene of fast-twitch muscle fibers [26], while Myh7 is important for slow-twitch muscle fibers [27]. |
About Function
| Enhancer function : | Recently, it was reported that m6A motif was sufficient to drive translation initiation in circRNAs; and m6A motif-driven translation required eukaryotic translation initiation factor 4 gamma 2 (eIF4G2) and m6A reader YTH domain family protein 3 (YTHDF3) in human cells [21]. Myh is divided into different subtypes, and Myh1 is the signature gene of fast-twitch muscle fibers [26], while Myh7 is important for slow-twitch muscle fibers [27]. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Recently, it was reported that m6A motif was sufficient to drive translation initiation in circRNAs; and m6A motif-driven translation required eukaryotic translation initiation factor 4 gamma 2 (eIF4G2) and m6A reader YTH domain family protein 3 (YTHDF3) in human cells [21]. Myh is divided into different subtypes, and Myh1 is the signature gene of fast-twitch muscle fibers [26], while Myh7 is important for slow-twitch muscle fibers [27]. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene