About Enhancer
| Enhancer ID: | E_02_0495 |
| Species: | human |
| Position : | chr5:122060306-122062306   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Atherosclerosis, coronary artery disease (cad) |
| Pubmed ID: | 30081225 |
| Enhancer experiment: | RT-PCR, immunofluorescence staining |
| Enhancer experiment description: | Expression of mediators of cholesterol transport, namely the lectin-like oxidized low-density lipoprotein receptor (LOX)-1 and ATP-binding cassette transporter (ABCA)-1, inflammatory markers tumor necrosis factor (TNF)-? and interleukin (IL)-1?/IL-6, nuclear-factor kappa-light-chain-enhancer of activated B cells (NF-?B), intracellular/vascular adhesion molecule(s) (VCAM-1, ICAM-1), and miRNAs (miR-221/ 21/ 1), associated with cardiovascular disease (CVD), were analyzed in cardiac tissue and coronary vasculature. |
About Target gene
| Target gene : | LOX |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Expression of mediators of cholesterol transport, namely the lectin-like oxidized low-density lipoprotein receptor (LOX)-1 and ATP-binding cassette transporter (ABCA)-1, inflammatory markers tumor necrosis factor (TNF)-? and interleukin (IL)-1?/IL-6, nuclear-factor kappa-light-chain-enhancer of activated B cells (NF-?B), intracellular/vascular adhesion molecule(s) (VCAM-1, ICAM-1), and miRNAs (miR-221/ 21/ 1), associated with cardiovascular disease (CVD), were analyzed in cardiac tissue and coronary vasculature. |
About TF
| TF name : | -- |
| TF experiment: | RT-PCR,?????? |
| TF experiment description: | Expression of mediators of cholesterol transport, namely the lectin-like oxidized low-density lipoprotein receptor (LOX)-1 and ATP-binding cassette transporter (ABCA)-1, inflammatory markers tumor necrosis factor (TNF)-? and interleukin (IL)-1?/IL-6, nuclear-factor kappa-light-chain-enhancer of activated B cells (NF-?B), intracellular/vascular adhesion molecule(s) (VCAM-1, ICAM-1), and miRNAs (miR-221/ 21/ 1), associated with cardiovascular disease (CVD), were analyzed in cardiac tissue and coronary vasculature. |
About Function
| Enhancer function : | Expression of mediators of cholesterol transport, namely the lectin-like oxidized low-density lipoprotein receptor (LOX)-1 and ATP-binding cassette transporter (ABCA)-1, inflammatory markers tumor necrosis factor (TNF)-? and interleukin (IL)-1?/IL-6, nuclear-factor kappa-light-chain-enhancer of activated B cells (NF-?B), intracellular/vascular adhesion molecule(s) (VCAM-1, ICAM-1), and miRNAs (miR-221/ 21/ 1), associated with cardiovascular disease (CVD), were analyzed in cardiac tissue and coronary vasculature. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Expression of mediators of cholesterol transport, namely the lectin-like oxidized low-density lipoprotein receptor (LOX)-1 and ATP-binding cassette transporter (ABCA)-1, inflammatory markers tumor necrosis factor (TNF)-? and interleukin (IL)-1?/IL-6, nuclear-factor kappa-light-chain-enhancer of activated B cells (NF-?B), intracellular/vascular adhesion molecule(s) (VCAM-1, ICAM-1), and miRNAs (miR-221/ 21/ 1), associated with cardiovascular disease (CVD), were analyzed in cardiac tissue and coronary vasculature. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene