About Enhancer
| Enhancer ID: |
E_02_0484 |
| Species: |
human |
| Position :
|
chr14:100776331-100778331  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
-- |
| Pubmed ID: |
30103943
|
| Enhancer experiment: |
Gene knockdown, fish, QRT PCR, Weston blot, chromatin immunoprecipitation (chip) - PCR assay, statistical analysis |
| Enhancer experiment description: |
Knockdown studies of MEG3 and EZH2 by siRNA showed that MEG3/EZH2 negatively regulated osteo- genesis of hDFSCs. |
About Target gene
| Target gene : |
MEG3(2900016C05Rik,3110050O07Rik,6330408G06Rik,AI425946,AW108224,D12Bwg1266e,Gtl2,R74756,R75394),EZH2 |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
Knockdown studies of MEG3 and EZH2 by siRNA showed that MEG3/EZH2 negatively regulated osteo- genesis of hDFSCs.;Knockdown studies of MEG3 and EZH2 by siRNA showed that MEG3/EZH2 negatively regulated osteo- genesis of hDFSCs. |
About TF
| TF name : |
-- |
| TF experiment: |
????,FISH, qRT-PCR,weston blot,Chromatin immunoprecipitation (ChIP)-PCR assay,???? |
| TF experiment description: |
Knockdown studies of MEG3 and EZH2 by siRNA showed that MEG3/EZH2 negatively regulated osteo- genesis of hDFSCs.;Knockdown studies of MEG3 and EZH2 by siRNA showed that MEG3/EZH2 negatively regulated osteo- genesis of hDFSCs. |
About Function
| Enhancer function : |
Knockdown studies of MEG3 and EZH2 by siRNA showed that MEG3/EZH2 negatively regulated osteo- genesis of hDFSCs. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function experiment description: |
Knockdown studies of MEG3 and EZH2 by siRNA showed that MEG3/EZH2 negatively regulated osteo- genesis of hDFSCs. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs