About Enhancer
| Enhancer ID: | E_02_0459 |
| Species: | human |
| Position : | chr5:69232175-69234175   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Leukemia |
| Pubmed ID: | 30146162 |
| Enhancer experiment: | RT-PCR,ChIP-seq,weston blot |
| Enhancer experiment description: | We show that blocking CKI? together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, and induce apoptosis. |
About Target gene
| Target gene : | CDK7,CDK9 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | We show that blocking CKI? together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, and induce apoptosis.;We show that blocking CKI? together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, and induce apoptosis. |
About TF
| TF name : | -- |
| TF experiment: | RT-PCR,ChIP-seq,weston blot |
| TF experiment description: | We show that blocking CKI? together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, and induce apoptosis.;We show that blocking CKI? together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, and induce apoptosis. |
About Function
| Enhancer function : | We show that blocking CKI? together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, and induce apoptosis. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
We show that blocking CKI? together with CDK7 and/or CDK9 synergistically stabilize p53, deprive leukemia cells of survival and proliferation-maintaining SE-driven oncogenes, and induce apoptosis. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene