About Enhancer
| Enhancer ID: | E_02_0436 |
| Species: | human |
| Position : | chr3:181709352-181711352   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Mammary cancer |
| Pubmed ID: | 30191953 |
| Enhancer experiment: | Flow cytometry, real ? time PCR, Western blot |
| Enhancer experiment description: | Overexpression of miR 302/367 cluster in MDA MB 231 and SK BR 3 breast cancer cells upregulated expression of miR 302/367 members and also some core pluripotency factors including OCT4A, SOX2 and NANOG, induced mesenchymal to epithelial transition, suppressed invasion, proliferation, and induced apoptosis in the both cell lines. |
About Target gene
| Target gene : | SOX2(ANOP3,MCOPS3) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Overexpression of miR 302/367 cluster in MDA MB 231 and SK BR 3 breast cancer cells upregulated expression of miR 302/367 members and also some core pluripotency factors including OCT4A, SOX2 and NANOG, induced mesenchymal to epithelial transition, suppressed invasion, proliferation, and induced apoptosis in the both cell lines. |
About TF
| TF name : | -- |
| TF experiment: | ?????,real?time PCR,westoon blot |
| TF experiment description: | Overexpression of miR 302/367 cluster in MDA MB 231 and SK BR 3 breast cancer cells upregulated expression of miR 302/367 members and also some core pluripotency factors including OCT4A, SOX2 and NANOG, induced mesenchymal to epithelial transition, suppressed invasion, proliferation, and induced apoptosis in the both cell lines. |
About Function
| Enhancer function : | Overexpression of miR 302/367 cluster in MDA MB 231 and SK BR 3 breast cancer cells upregulated expression of miR 302/367 members and also some core pluripotency factors including OCT4A, SOX2 and NANOG, induced mesenchymal to epithelial transition, suppressed invasion, proliferation, and induced apoptosis in the both cell lines. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Overexpression of miR 302/367 cluster in MDA MB 231 and SK BR 3 breast cancer cells upregulated expression of miR 302/367 members and also some core pluripotency factors including OCT4A, SOX2 and NANOG, induced mesenchymal to epithelial transition, suppressed invasion, proliferation, and induced apoptosis in the both cell lines. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene