About Enhancer
| Enhancer ID: | E_02_0435 |
| Species: | human |
| Position : | chr8:81475654-81477654   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Obesity |
| Pubmed ID: | 30195387 |
| Enhancer experiment: | RT-PCR, immunofluorescence light staining, Western blot |
| Enhancer experiment description: | Diazinon has been known to induce neurotoxic effects mainly through the inhibition of acetylcholinesterase (AChE). Diazinon significantly induced protein expression of transcriptional factors CCAAT-enhancer-binding proteins ? (C/EBP?) and peroxisome proliferator-activated receptor ? (PPAR?), their downstream proteins, fatty acid synthase (FASN), acetyl CoA carboxylase (ACC), fatty acid-binding protein 4 (FABP4), lipoprotein lipase (LPL), adiponectin and perilipin in dose and time-dependent manners. |
About Target gene
| Target gene : | FABP4,FASN |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Diazinon has been known to induce neurotoxic effects mainly through the inhibition of acetylcholinesterase (AChE). Diazinon significantly induced protein expression of transcriptional factors CCAAT-enhancer-binding proteins ? (C/EBP?) and peroxisome proliferator-activated receptor ? (PPAR?), their downstream proteins, fatty acid synthase (FASN), acetyl CoA carboxylase (ACC), fatty acid-binding protein 4 (FABP4), lipoprotein lipase (LPL), adiponectin and perilipin in dose and time-dependent manners. ;Diazinon has been known to induce neurotoxic effects mainly through the inhibition of acetylcholinesterase (AChE). Diazinon significantly induced protein expression of transcriptional factors CCAAT-enhancer-binding proteins ? (C/EBP?) and peroxisome proliferator-activated receptor ? (PPAR?), their downstream proteins, fatty acid synthase (FASN), acetyl CoA carboxylase (ACC), fatty acid-binding protein 4 (FABP4), lipoprotein lipase (LPL), adiponectin and perilipin in dose and time-dependent manners. |
About TF
| TF name : | -- |
| TF experiment: | RT-PCR,???????,Western Blot |
| TF experiment description: | Diazinon has been known to induce neurotoxic effects mainly through the inhibition of acetylcholinesterase (AChE). Diazinon significantly induced protein expression of transcriptional factors CCAAT-enhancer-binding proteins ? (C/EBP?) and peroxisome proliferator-activated receptor ? (PPAR?), their downstream proteins, fatty acid synthase (FASN), acetyl CoA carboxylase (ACC), fatty acid-binding protein 4 (FABP4), lipoprotein lipase (LPL), adiponectin and perilipin in dose and time-dependent manners. ;Diazinon has been known to induce neurotoxic effects mainly through the inhibition of acetylcholinesterase (AChE). Diazinon significantly induced protein expression of transcriptional factors CCAAT-enhancer-binding proteins ? (C/EBP?) and peroxisome proliferator-activated receptor ? (PPAR?), their downstream proteins, fatty acid synthase (FASN), acetyl CoA carboxylase (ACC), fatty acid-binding protein 4 (FABP4), lipoprotein lipase (LPL), adiponectin and perilipin in dose and time-dependent manners. |
About Function
| Enhancer function : | Diazinon has been known to induce neurotoxic effects mainly through the inhibition of acetylcholinesterase (AChE). Diazinon significantly induced protein expression of transcriptional factors CCAAT-enhancer-binding proteins ? (C/EBP?) and peroxisome proliferator-activated receptor ? (PPAR?), their downstream proteins, fatty acid synthase (FASN), acetyl CoA carboxylase (ACC), fatty acid-binding protein 4 (FABP4), lipoprotein lipase (LPL), adiponectin and perilipin in dose and time-dependent manners. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Diazinon has been known to induce neurotoxic effects mainly through the inhibition of acetylcholinesterase (AChE). Diazinon significantly induced protein expression of transcriptional factors CCAAT-enhancer-binding proteins ? (C/EBP?) and peroxisome proliferator-activated receptor ? (PPAR?), their downstream proteins, fatty acid synthase (FASN), acetyl CoA carboxylase (ACC), fatty acid-binding protein 4 (FABP4), lipoprotein lipase (LPL), adiponectin and perilipin in dose and time-dependent manners. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene