About Enhancer
| Enhancer ID: | E_02_0432 |
| Species: | human |
| Position : | chr11:27652477-27654477   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Depression |
| Pubmed ID: | 30196018 |
| Enhancer experiment: | qPCR,weston blot |
| Enhancer experiment description: | Moreover, SAK3 administration (0.5 mg/kg, p.o.) antagonized the reduction of calcium/calmodulin-dependent protein kinase II (CaMKII) and CaMKIV phosphorylation levels, thereby rescuing the decreased levels of cAMP response element- binding protein (CREB)/brain derived neurotrophic factor (BDNF) signaling in the OBX DG. |
About Target gene
| Target gene : | BDNF |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Moreover, SAK3 administration (0.5 mg/kg, p.o.) antagonized the reduction of calcium/calmodulin-dependent protein kinase II (CaMKII) and CaMKIV phosphorylation levels, thereby rescuing the decreased levels of cAMP response element- binding protein (CREB)/brain derived neurotrophic factor (BDNF) signaling in the OBX DG. |
About TF
| TF name : | -- |
| TF experiment: | qPCR,weston blot |
| TF experiment description: | Moreover, SAK3 administration (0.5 mg/kg, p.o.) antagonized the reduction of calcium/calmodulin-dependent protein kinase II (CaMKII) and CaMKIV phosphorylation levels, thereby rescuing the decreased levels of cAMP response element- binding protein (CREB)/brain derived neurotrophic factor (BDNF) signaling in the OBX DG. |
About Function
| Enhancer function : | Moreover, SAK3 administration (0.5 mg/kg, p.o.) antagonized the reduction of calcium/calmodulin-dependent protein kinase II (CaMKII) and CaMKIV phosphorylation levels, thereby rescuing the decreased levels of cAMP response element- binding protein (CREB)/brain derived neurotrophic factor (BDNF) signaling in the OBX DG. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Moreover, SAK3 administration (0.5 mg/kg, p.o.) antagonized the reduction of calcium/calmodulin-dependent protein kinase II (CaMKII) and CaMKIV phosphorylation levels, thereby rescuing the decreased levels of cAMP response element- binding protein (CREB)/brain derived neurotrophic factor (BDNF) signaling in the OBX DG. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene