About Enhancer
| Enhancer ID: | E_02_0424 |
| Species: | human |
| Position : | chr1:247413632-247415632   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Non alcoholic fatty liver disease, inflammation, liver fibrosis |
| Pubmed ID: | 30208322 |
| Enhancer experiment: | qRT-PCR,weston blot |
| Enhancer experiment description: | Emerging evidence suggests that the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in hepatocytes plays a role in the pathogenesis of liver diseases (Szabo and Csak, 2012; Szabo and Petrasek, 2015). Fxr deficiency in mice augmented the ability of ER stress to induce NLRP3 and thioredoxin-interacting protein (TXNIP), whereas FXR ligand activation prevented it, ameliorating liver injury. |
About Target gene
| Target gene : | NLRP3,TXNIP |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Emerging evidence suggests that the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in hepatocytes plays a role in the pathogenesis of liver diseases (Szabo and Csak, 2012; Szabo and Petrasek, 2015). Fxr deficiency in mice augmented the ability of ER stress to induce NLRP3 and thioredoxin-interacting protein (TXNIP), whereas FXR ligand activation prevented it, ameliorating liver injury. ;Emerging evidence suggests that the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in hepatocytes plays a role in the pathogenesis of liver diseases (Szabo and Csak, 2012; Szabo and Petrasek, 2015). Fxr deficiency in mice augmented the ability of ER stress to induce NLRP3 and thioredoxin-interacting protein (TXNIP), whereas FXR ligand activation prevented it, ameliorating liver injury. |
About TF
| TF name : | -- |
| TF experiment: | qRT-PCR,weston blot |
| TF experiment description: | Emerging evidence suggests that the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in hepatocytes plays a role in the pathogenesis of liver diseases (Szabo and Csak, 2012; Szabo and Petrasek, 2015). Fxr deficiency in mice augmented the ability of ER stress to induce NLRP3 and thioredoxin-interacting protein (TXNIP), whereas FXR ligand activation prevented it, ameliorating liver injury. ;Emerging evidence suggests that the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in hepatocytes plays a role in the pathogenesis of liver diseases (Szabo and Csak, 2012; Szabo and Petrasek, 2015). Fxr deficiency in mice augmented the ability of ER stress to induce NLRP3 and thioredoxin-interacting protein (TXNIP), whereas FXR ligand activation prevented it, ameliorating liver injury. |
About Function
| Enhancer function : | Emerging evidence suggests that the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in hepatocytes plays a role in the pathogenesis of liver diseases (Szabo and Csak, 2012; Szabo and Petrasek, 2015). Fxr deficiency in mice augmented the ability of ER stress to induce NLRP3 and thioredoxin-interacting protein (TXNIP), whereas FXR ligand activation prevented it, ameliorating liver injury. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Emerging evidence suggests that the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in hepatocytes plays a role in the pathogenesis of liver diseases (Szabo and Csak, 2012; Szabo and Petrasek, 2015). Fxr deficiency in mice augmented the ability of ER stress to induce NLRP3 and thioredoxin-interacting protein (TXNIP), whereas FXR ligand activation prevented it, ameliorating liver injury. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene