About Enhancer
| Enhancer ID: | E_02_0418 |
| Species: | mouse |
| Position : | chr17:85989752-85991752   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Kidney disease |
| Pubmed ID: | 29377931 |
| Enhancer experiment: | ChIP-seq,4C-seq,Genomic Regions Enrichment of Annotations Tool (GREAT) analysis,Fluorescence-activated cell sorting,RNA-seq,qPCR,Electrophoretic mobility shift assay (EMSA),Immunoprecipitations,Immunoprecipitations |
| Enhancer experiment description: | Nephron progenitor number determines nephron endowment; a reduced nephron count is linked to the onset of kidney disease. Several transcriptional regulators including Six2, Wt1, Osr1, Sall1, Eya1, Pax2, and Hox11 paralogues are required for specification and/or maintenance of nephron progenitors. |
About Target gene
| Target gene : | Six2(Six2) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Nephron progenitor number determines nephron endowment; a reduced nephron count is linked to the onset of kidney disease. Several transcriptional regulators including Six2, Wt1, Osr1, Sall1, Eya1, Pax2, and Hox11 paralogues are required for specification and/or maintenance of nephron progenitors. |
About TF
| TF name : | -- |
| TF experiment: | ChIP-seq,4C-seq,Genomic Regions Enrichment of Annotations Tool (GREAT) analysis,Fluorescence-activated cell sorting,RNA-seq,qPCR,Electrophoretic mobility shift assay (EMSA),Immunoprecipitations,Immunoprecipitations |
| TF experiment description: | Nephron progenitor number determines nephron endowment; a reduced nephron count is linked to the onset of kidney disease. Several transcriptional regulators including Six2, Wt1, Osr1, Sall1, Eya1, Pax2, and Hox11 paralogues are required for specification and/or maintenance of nephron progenitors. |
About Function
| Enhancer function : | Nephron progenitor number determines nephron endowment; a reduced nephron count is linked to the onset of kidney disease. Several transcriptional regulators including Six2, Wt1, Osr1, Sall1, Eya1, Pax2, and Hox11 paralogues are required for specification and/or maintenance of nephron progenitors. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Nephron progenitor number determines nephron endowment; a reduced nephron count is linked to the onset of kidney disease. Several transcriptional regulators including Six2, Wt1, Osr1, Sall1, Eya1, Pax2, and Hox11 paralogues are required for specification and/or maintenance of nephron progenitors. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene