About Enhancer
| Enhancer ID: | E_02_0395 |
| Species: | human |
| Position : | chr5:138462782-138464782   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Head and neck squamous cell carcinoma |
| Pubmed ID: | 30396177 |
| Enhancer experiment: | TCGA RNAseq,Immunohistochemical analysis, overexpression vector transfection,Quantitative real-time PCR (qPCR),Western blot,Matrigel invasion assay,Promoterluciferase assay,Chromatin immunoprecipitation (ChIP) analysis |
| Enhancer experiment description: | Our data suggests that EGR1 prevents HNSCC metastasis through downregulation of MMP9 and MDM2. EGR1 might be a potential candidate to attenuate HNSCC metastasis. |
About Target gene
| Target gene : | EGR1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Our data suggests that EGR1 prevents HNSCC metastasis through downregulation of MMP9 and MDM2. EGR1 might be a potential candidate to attenuate HNSCC metastasis. |
About TF
| TF name : | -- |
| TF experiment: | TCGA RNAseq,Immunohistochemical analysis, overexpression vector transfection,Quantitative real-time PCR (qPCR),Western blot,Matrigel invasion assay,Promoterluciferase assay,Chromatin immunoprecipitation (ChIP) analysis |
| TF experiment description: | Our data suggests that EGR1 prevents HNSCC metastasis through downregulation of MMP9 and MDM2. EGR1 might be a potential candidate to attenuate HNSCC metastasis. |
About Function
| Enhancer function : | Our data suggests that EGR1 prevents HNSCC metastasis through downregulation of MMP9 and MDM2. EGR1 might be a potential candidate to attenuate HNSCC metastasis. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Our data suggests that EGR1 prevents HNSCC metastasis through downregulation of MMP9 and MDM2. EGR1 might be a potential candidate to attenuate HNSCC metastasis. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene