About Enhancer
| Enhancer ID: |
E_02_0386 |
| Species: |
human |
| Position :
|
chrX:49247427-49249427
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Autoimmune diseases |
| Pubmed ID: |
30446251
|
| Enhancer experiment: |
Surface plasmon resonance,DNA demethylation of FOXP3 and CTLA4, |
| Enhancer experiment description: |
The expanded human Tregs had demethylated FOXP3 and CTLA4 signatures and were immunosuppressive. These results describe a next-generation immunotherapy using a long-lived and Treg-selective IL-2 that activates and expands functional Tregs in vivo. |
About Target gene
| Target gene : |
FOXP3 |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
The expanded human Tregs had demethylated FOXP3 and CTLA4 signatures and were immunosuppressive. These results describe a next-generation immunotherapy using a long-lived and Treg-selective IL-2 that activates and expands functional Tregs in vivo. |
About TF
| TF name : |
-- |
| TF experiment: |
Surface plasmon resonance,DNA demethylation of FOXP3 and CTLA4, |
| TF experiment description: |
The expanded human Tregs had demethylated FOXP3 and CTLA4 signatures and were immunosuppressive. These results describe a next-generation immunotherapy using a long-lived and Treg-selective IL-2 that activates and expands functional Tregs in vivo. |
About Function
| Enhancer function : |
The expanded human Tregs had demethylated FOXP3 and CTLA4 signatures and were immunosuppressive. These results describe a next-generation immunotherapy using a long-lived and Treg-selective IL-2 that activates and expands functional Tregs in vivo. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
The expanded human Tregs had demethylated FOXP3 and CTLA4 signatures and were immunosuppressive. These results describe a next-generation immunotherapy using a long-lived and Treg-selective IL-2 that activates and expands functional Tregs in vivo. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs