About Enhancer
| Enhancer ID: | E_02_0374 |
| Species: | mouse |
| Position : | chr11:6414970-6416970   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Hypertriglyceridemia |
| Pubmed ID: | 32302712 |
| Enhancer experiment: | RNA extraction and Transcriptome sequencing?Quantitative real-time PCR?RACE?RNA immunoprecipitation?Chromatin immunoprecipitation |
| Enhancer experiment description: | On the one hand, Lnc19959.2 up-regulate ApoA4 expression via ubiquitinated transcription inhibitor factor Purb; on the other hand, lnc19959.2-hnRNPA2B1 complex acts on Cpt1a, Tm7sf2 and Gpam in some ways to reduce the efficiency of RNA polymerase II occupy on the target gene promoter. |
About Target gene
| Target gene : | Purb |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | On the one hand, Lnc19959.2 up-regulate ApoA4 expression via ubiquitinated transcription inhibitor factor Purb; on the other hand, lnc19959.2-hnRNPA2B1 complex acts on Cpt1a, Tm7sf2 and Gpam in some ways to reduce the efficiency of RNA polymerase II occupy on the target gene promoter. |
About TF
| TF name : | -- |
| TF experiment: | RNA extraction and Transcriptome sequencing?Quantitative real-time PCR?RACE?RNA immunoprecipitation?Chromatin immunoprecipitation |
| TF experiment description: | On the one hand, Lnc19959.2 up-regulate ApoA4 expression via ubiquitinated transcription inhibitor factor Purb; on the other hand, lnc19959.2-hnRNPA2B1 complex acts on Cpt1a, Tm7sf2 and Gpam in some ways to reduce the efficiency of RNA polymerase II occupy on the target gene promoter. |
About Function
| Enhancer function : | On the one hand, Lnc19959.2 up-regulate ApoA4 expression via ubiquitinated transcription inhibitor factor Purb; on the other hand, lnc19959.2-hnRNPA2B1 complex acts on Cpt1a, Tm7sf2 and Gpam in some ways to reduce the efficiency of RNA polymerase II occupy on the target gene promoter. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
On the one hand, Lnc19959.2 up-regulate ApoA4 expression via ubiquitinated transcription inhibitor factor Purb; on the other hand, lnc19959.2-hnRNPA2B1 complex acts on Cpt1a, Tm7sf2 and Gpam in some ways to reduce the efficiency of RNA polymerase II occupy on the target gene promoter. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene