About Enhancer
| Enhancer ID: | E_02_0373 |
| Species: | human |
| Position : | chr7:148804089-148806089   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Febrile seizures |
| Pubmed ID: | 32298702 |
| Enhancer experiment: | Enzyme-linked immunosorbent assay?Western blot?qRT-PCR |
| Enhancer experiment description: | In addition, a significant increase in the pro-inflammatory cytokine (IL-1? and TNF-?) levels was observed in rats after GSK 126 treatment, and IL-1? administration increased seizure severity, suggesting that the inflammatory response was involved in the regulation of seizure development by EZH2. |
About Target gene
| Target gene : | EZH2 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | In addition, a significant increase in the pro-inflammatory cytokine (IL-1? and TNF-?) levels was observed in rats after GSK 126 treatment, and IL-1? administration increased seizure severity, suggesting that the inflammatory response was involved in the regulation of seizure development by EZH2. |
About TF
| TF name : | -- |
| TF experiment: | Enzyme-linked immunosorbent assay?Western blot?qRT-PCR |
| TF experiment description: | In addition, a significant increase in the pro-inflammatory cytokine (IL-1? and TNF-?) levels was observed in rats after GSK 126 treatment, and IL-1? administration increased seizure severity, suggesting that the inflammatory response was involved in the regulation of seizure development by EZH2. |
About Function
| Enhancer function : | In addition, a significant increase in the pro-inflammatory cytokine (IL-1? and TNF-?) levels was observed in rats after GSK 126 treatment, and IL-1? administration increased seizure severity, suggesting that the inflammatory response was involved in the regulation of seizure development by EZH2. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
In addition, a significant increase in the pro-inflammatory cytokine (IL-1? and TNF-?) levels was observed in rats after GSK 126 treatment, and IL-1? administration increased seizure severity, suggesting that the inflammatory response was involved in the regulation of seizure development by EZH2. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene