About Enhancer
| Enhancer ID: | E_02_0371 |
| Species: | human |
| Position : | chr5:36149227-36151227   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Acute myeloid leukemia |
| Pubmed ID: | 32622945 |
| Enhancer experiment: | Western blot?Co-immunoprecipitation?Immunophenotyping analysis?flow cytometer?Quantitative real-time PCR |
| Enhancer experiment description: | Using Estradiol-inducible K562-C/EBP?-ER cells as yet another model of granulocytic differentiation, we further confirmed that SKP2 overexpression indeed inhibits granulocytic differentiation by mitigating C/EBP? stability. |
About Target gene
| Target gene : | SKP2 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Using Estradiol-inducible K562-C/EBP?-ER cells as yet another model of granulocytic differentiation, we further confirmed that SKP2 overexpression indeed inhibits granulocytic differentiation by mitigating C/EBP? stability. |
About TF
| TF name : | -- |
| TF experiment: | Western blot?Co-immunoprecipitation?Immunophenotyping analysis?flow cytometer?Quantitative real-time PCR |
| TF experiment description: | Using Estradiol-inducible K562-C/EBP?-ER cells as yet another model of granulocytic differentiation, we further confirmed that SKP2 overexpression indeed inhibits granulocytic differentiation by mitigating C/EBP? stability. |
About Function
| Enhancer function : | Using Estradiol-inducible K562-C/EBP?-ER cells as yet another model of granulocytic differentiation, we further confirmed that SKP2 overexpression indeed inhibits granulocytic differentiation by mitigating C/EBP? stability. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Using Estradiol-inducible K562-C/EBP?-ER cells as yet another model of granulocytic differentiation, we further confirmed that SKP2 overexpression indeed inhibits granulocytic differentiation by mitigating C/EBP? stability. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene