About Enhancer
| Enhancer ID: | E_02_0368 |
| Species: | mouse |
| Position : | chr3:8725839-8727839   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Nasopharynx cancer |
| Pubmed ID: | 32554463 |
| Enhancer experiment: | immunohistochemistry?Section in situ hybridization?ATAC-seq?RNA-seq? |
| Enhancer experiment description: | Unlike Ezh2 loss-of-function, dual inactivation of Ezh1 and Ezh2 triggered overexpression of the transcriptional repressor Hesrelated family BHLH transcription factor with YRPW motif 1 (Hey1), downregulation of Six2, and unscheduled activation of Wnt4-driven differentiation, resulting in early termination of nephrogenesis and severe renal dysgenesis. |
About Target gene
| Target gene : | Hey1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Unlike Ezh2 loss-of-function, dual inactivation of Ezh1 and Ezh2 triggered overexpression of the transcriptional repressor Hesrelated family BHLH transcription factor with YRPW motif 1 (Hey1), downregulation of Six2, and unscheduled activation of Wnt4-driven differentiation, resulting in early termination of nephrogenesis and severe renal dysgenesis. |
About TF
| TF name : | -- |
| TF experiment: | immunohistochemistry?Section in situ hybridization?ATAC-seq?RNA-seq? |
| TF experiment description: | Unlike Ezh2 loss-of-function, dual inactivation of Ezh1 and Ezh2 triggered overexpression of the transcriptional repressor Hesrelated family BHLH transcription factor with YRPW motif 1 (Hey1), downregulation of Six2, and unscheduled activation of Wnt4-driven differentiation, resulting in early termination of nephrogenesis and severe renal dysgenesis. |
About Function
| Enhancer function : | Unlike Ezh2 loss-of-function, dual inactivation of Ezh1 and Ezh2 triggered overexpression of the transcriptional repressor Hesrelated family BHLH transcription factor with YRPW motif 1 (Hey1), downregulation of Six2, and unscheduled activation of Wnt4-driven differentiation, resulting in early termination of nephrogenesis and severe renal dysgenesis. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Unlike Ezh2 loss-of-function, dual inactivation of Ezh1 and Ezh2 triggered overexpression of the transcriptional repressor Hesrelated family BHLH transcription factor with YRPW motif 1 (Hey1), downregulation of Six2, and unscheduled activation of Wnt4-driven differentiation, resulting in early termination of nephrogenesis and severe renal dysgenesis. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene