About Enhancer
| Enhancer ID: | E_02_0358 |
| Species: | human |
| Position : | chr5:51380949-51382949   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Diabetic peripheral |
| Pubmed ID: | 32544883 |
| Enhancer experiment: | Dual luciferase reporter gene assay?RT-qPCR?Western blot?Immunohistochemistry |
| Enhancer experiment description: | Modulated expression of neurotrophic factors in sciatic nerves in rats with DM developed by intraperitoneal injection of 0.45% streptozotocin, suggesting that ISL1 could delay DM progression and promote neural regeneration and repair after sciatic nerve damage. |
About Target gene
| Target gene : | ISL1(ISLET1,Isl-1) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Modulated expression of neurotrophic factors in sciatic nerves in rats with DM developed by intraperitoneal injection of 0.45% streptozotocin, suggesting that ISL1 could delay DM progression and promote neural regeneration and repair after sciatic nerve damage. |
About TF
| TF name : | -- |
| TF experiment: | Dual luciferase reporter gene assay?RT-qPCR?Western blot?Immunohistochemistry |
| TF experiment description: | Modulated expression of neurotrophic factors in sciatic nerves in rats with DM developed by intraperitoneal injection of 0.45% streptozotocin, suggesting that ISL1 could delay DM progression and promote neural regeneration and repair after sciatic nerve damage. |
About Function
| Enhancer function : | Modulated expression of neurotrophic factors in sciatic nerves in rats with DM developed by intraperitoneal injection of 0.45% streptozotocin, suggesting that ISL1 could delay DM progression and promote neural regeneration and repair after sciatic nerve damage. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Modulated expression of neurotrophic factors in sciatic nerves in rats with DM developed by intraperitoneal injection of 0.45% streptozotocin, suggesting that ISL1 could delay DM progression and promote neural regeneration and repair after sciatic nerve damage. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene