About Enhancer
| Enhancer ID: | E_02_0341 |
| Species: | mouse |
| Position : | chr10:126881148-126883148   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Periodontal disease |
| Pubmed ID: | 29637561 |
| Enhancer experiment: | Computer-assisted Image Analysis,Quantitative Real-time PCR,Immunohistochemical Staining,Histochemical Staining,micro-computed tomography (micro-CT), |
| Enhancer experiment description: | 1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner. |
About Target gene
| Target gene : | Cyp27b1,VDR(Nr1i1),MMP3,MMP8 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | 1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner.;1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner.;1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner.;1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner. |
About TF
| TF name : | -- |
| TF experiment: | Computer-assisted Image Analysis,Quantitative Real-time PCR,Immunohistochemical Staining,Histochemical Staining,micro-computed tomography (micro-CT), |
| TF experiment description: | 1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner.;1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner.;1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner.;1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner. |
About Function
| Enhancer function : | 1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
1,25(OH)2 D deficiency in the 1?(OH)ase mice accelerated alveolar bone loss by inhibiting osteoblastic bone formation and enhancing periodontal tissue degeneration in a calcium- and phosphorus- as well as an age-independent manner. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene