About Enhancer
| Enhancer ID: | E_02_0325 |
| Species: | human |
| Position : | chr11:2161549-2163549   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Immunosenescence, inflammation |
| Pubmed ID: | 29691190 |
| Enhancer experiment: | MTT assays,Western blot,NO production,Assays for antioxidant enzymes,assays for lipid peroxidation,ELISA, |
| Enhancer experiment description: | NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN-? production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-?B p65 and p50. |
About Target gene
| Target gene : | TH |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN-? production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-?B p65 and p50. |
About TF
| TF name : | -- |
| TF experiment: | MTT assays,Western blot,NO production,Assays for antioxidant enzymes,assays for lipid peroxidation,ELISA, |
| TF experiment description: | NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN-? production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-?B p65 and p50. |
About Function
| Enhancer function : | NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN-? production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-?B p65 and p50. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN-? production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-?B p65 and p50. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene