About Enhancer
| Enhancer ID: | E_02_0297 |
| Species: | human |
| Position : | chr17:63474572-63476572   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Low peak bone mass |
| Pubmed ID: | 29844424 |
| Enhancer experiment: | ELISA,Total RNA extraction,RT-qPCR,Alizarin Red S staining,siRNA knockdown,Western blot,Histological,immunohistochemistry analysis,Chromatin immunoprecipitation (ChIP) assay |
| Enhancer experiment description: | In conclusion, PDE induced the low peak bone mass and its intergenerational effect, which was mediated by sustained activation of RAS via increasing H3K27ac level of ACE. |
About Target gene
| Target gene : | ACE |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | In conclusion, PDE induced the low peak bone mass and its intergenerational effect, which was mediated by sustained activation of RAS via increasing H3K27ac level of ACE. |
About TF
| TF name : | -- |
| TF experiment: | ELISA,Total RNA extraction,RT-qPCR,Alizarin Red S staining,siRNA knockdown,Western blot,Histological,immunohistochemistry analysis,Chromatin immunoprecipitation (ChIP) assay |
| TF experiment description: | In conclusion, PDE induced the low peak bone mass and its intergenerational effect, which was mediated by sustained activation of RAS via increasing H3K27ac level of ACE. |
About Function
| Enhancer function : | In conclusion, PDE induced the low peak bone mass and its intergenerational effect, which was mediated by sustained activation of RAS via increasing H3K27ac level of ACE. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
In conclusion, PDE induced the low peak bone mass and its intergenerational effect, which was mediated by sustained activation of RAS via increasing H3K27ac level of ACE. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene