About Enhancer
| Enhancer ID: |
E_02_0289 |
| Species: |
human |
| Position :
|
chr13:30454393-30456393
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Inflammation in cerebral ischemia, reperfusion injury |
| Pubmed ID: |
29867706
|
| Enhancer experiment: |
Nissl staining, ELISA,immunofluorescence staining,Western Blot,immunohistochemical staining |
| Enhancer experiment description: |
We provide novel evidence that UA reduces inflammatory cytokine production to protect the brain from cerebral ischemia and reperfusion injury possibly through the HMGB1/TLR4/NF?B signaling pathway. |
About Target gene
| Target gene : |
HMGB1,TLR4(Lps,Ly87,Ran/M1,Rasl2-8) |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
We provide novel evidence that UA reduces inflammatory cytokine production to protect the brain from cerebral ischemia and reperfusion injury possibly through the HMGB1/TLR4/NF?B signaling pathway.;We provide novel evidence that UA reduces inflammatory cytokine production to protect the brain from cerebral ischemia and reperfusion injury possibly through the HMGB1/TLR4/NF?B signaling pathway. |
About TF
| TF name : |
-- |
| TF experiment: |
Nissl staining, ELISA,immunofluorescence staining,Western Blot,immunohistochemical staining |
| TF experiment description: |
We provide novel evidence that UA reduces inflammatory cytokine production to protect the brain from cerebral ischemia and reperfusion injury possibly through the HMGB1/TLR4/NF?B signaling pathway.;We provide novel evidence that UA reduces inflammatory cytokine production to protect the brain from cerebral ischemia and reperfusion injury possibly through the HMGB1/TLR4/NF?B signaling pathway. |
About Function
| Enhancer function : |
We provide novel evidence that UA reduces inflammatory cytokine production to protect the brain from cerebral ischemia and reperfusion injury possibly through the HMGB1/TLR4/NF?B signaling pathway. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
We provide novel evidence that UA reduces inflammatory cytokine production to protect the brain from cerebral ischemia and reperfusion injury possibly through the HMGB1/TLR4/NF?B signaling pathway. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs