About Enhancer
| Enhancer ID: |
E_02_0266 |
| Species: |
human |
| Position :
|
chr6:45325473-45327473
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Acute leukemia |
| Pubmed ID: |
30971697
|
| Enhancer experiment: |
Immunohistochemistry, flow cytometry, DNA SEQ, RNA SEQ, RT-PCR, Western blot |
| Enhancer experiment description: |
RUNX2 ensures the expression of pDC-signature genes in leukemic cells, but also confers survival and proliferative properties in BPDCN cells. |
About Target gene
| Target gene : |
RUNX2(AML3,CBF-alpha-1,CBFA1,CCD,CCD1,CLCD,OSF-2,OSF2,PEA2aA,PEBP2aA) |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
RUNX2 ensures the expression of pDC-signature genes in leukemic cells, but also confers survival and proliferative properties in BPDCN cells. |
About TF
| TF name : |
-- |
| TF experiment: |
???????????DNA-seq?RNA-seq?RT-PCR?western blot |
| TF experiment description: |
RUNX2 ensures the expression of pDC-signature genes in leukemic cells, but also confers survival and proliferative properties in BPDCN cells. |
About Function
| Enhancer function : |
RUNX2 ensures the expression of pDC-signature genes in leukemic cells, but also confers survival and proliferative properties in BPDCN cells. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
RUNX2 ensures the expression of pDC-signature genes in leukemic cells, but also confers survival and proliferative properties in BPDCN cells. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs