About Enhancer
| Enhancer ID: | E_02_0265 |
| Species: | human |
| Position : | chr1:247412836-247414836   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Peritonitis |
| Pubmed ID: | 30976167 |
| Enhancer experiment: | RT-PCR?qPCR |
| Enhancer experiment description: | SF containing ginsenosides attenuates cytokine secretion by inhibiting the priming and activation steps of inflammasome activation, whereas NS induces upregulation of IL-1? precursor and nucleotide-binding and oligomerization domain (NOD)2like receptor protein 3 (NLRP3), which are key inflammasome components, via interaction with TLR4 [4], [10]. In addition, a high dose of RGE presents a more SF predominant effect (antiinflammasome), whereas low concentration of RGE shows NS-like efficacy (proinflammasome) in macrophages [10]. |
About Target gene
| Target gene : | NLRP3,NLRP4 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | SF containing ginsenosides attenuates cytokine secretion by inhibiting the priming and activation steps of inflammasome activation, whereas NS induces upregulation of IL-1? precursor and nucleotide-binding and oligomerization domain (NOD)2like receptor protein 3 (NLRP3), which are key inflammasome components, via interaction with TLR4 [4], [10]. In addition, a high dose of RGE presents a more SF predominant effect (antiinflammasome), whereas low concentration of RGE shows NS-like efficacy (proinflammasome) in macrophages [10].;SF containing ginsenosides attenuates cytokine secretion by inhibiting the priming and activation steps of inflammasome activation, whereas NS induces upregulation of IL-1? precursor and nucleotide-binding and oligomerization domain (NOD)3like receptor p |
About TF
| TF name : | -- |
| TF experiment: | RT-PCR?qPCR |
| TF experiment description: | SF containing ginsenosides attenuates cytokine secretion by inhibiting the priming and activation steps of inflammasome activation, whereas NS induces upregulation of IL-1? precursor and nucleotide-binding and oligomerization domain (NOD)2like receptor protein 3 (NLRP3), which are key inflammasome components, via interaction with TLR4 [4], [10]. In addition, a high dose of RGE presents a more SF predominant effect (antiinflammasome), whereas low concentration of RGE shows NS-like efficacy (proinflammasome) in macrophages [10].;SF containing ginsenosides attenuates cytokine secretion by inhibiting the priming and activation steps of inflammasome activation, whereas NS induces upregulation of IL-1? precursor and nucleotide-binding and oligomerization domain (NOD)3like receptor p |
About Function
| Enhancer function : | SF containing ginsenosides attenuates cytokine secretion by inhibiting the priming and activation steps of inflammasome activation, whereas NS induces upregulation of IL-1? precursor and nucleotide-binding and oligomerization domain (NOD)2like receptor protein 3 (NLRP3), which are key inflammasome components, via interaction with TLR4 [4], [10]. In addition, a high dose of RGE presents a more SF predominant effect (antiinflammasome), whereas low concentration of RGE shows NS-like efficacy (proinflammasome) in macrophages [10]. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
SF containing ginsenosides attenuates cytokine secretion by inhibiting the priming and activation steps of inflammasome activation, whereas NS induces upregulation of IL-1? precursor and nucleotide-binding and oligomerization domain (NOD)2like receptor protein 3 (NLRP3), which are key inflammasome components, via interaction with TLR4 [4], [10]. In addition, a high dose of RGE presents a more SF predominant effect (antiinflammasome), whereas low concentration of RGE shows NS-like efficacy (proinflammasome) in macrophages [10]. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene