About Enhancer
| Enhancer ID: | E_02_0249 |
| Species: | human |
| Position : | chr13:30454192-30456192   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Renal impairment |
| Pubmed ID: | 30651760 |
| Enhancer experiment: | PCR, sequencing technology |
| Enhancer experiment description: | The results of the RT-qPCR demonstrated that hypoxia stimulation increased the expression of HMGB1, PPAR, RAGE and TNF-? mRNA, and decreased the expression of SIRT1 mRNA in kidney tissues (P<0.05). |
About Target gene
| Target gene : | HMGB1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | The results of the RT-qPCR demonstrated that hypoxia stimulation increased the expression of HMGB1, PPAR, RAGE and TNF-? mRNA, and decreased the expression of SIRT1 mRNA in kidney tissues (P<0.05). |
About TF
| TF name : | -- |
| TF experiment: | PCR????? |
| TF experiment description: | The results of the RT-qPCR demonstrated that hypoxia stimulation increased the expression of HMGB1, PPAR, RAGE and TNF-? mRNA, and decreased the expression of SIRT1 mRNA in kidney tissues (P<0.05). |
About Function
| Enhancer function : | The results of the RT-qPCR demonstrated that hypoxia stimulation increased the expression of HMGB1, PPAR, RAGE and TNF-? mRNA, and decreased the expression of SIRT1 mRNA in kidney tissues (P<0.05). |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
The results of the RT-qPCR demonstrated that hypoxia stimulation increased the expression of HMGB1, PPAR, RAGE and TNF-? mRNA, and decreased the expression of SIRT1 mRNA in kidney tissues (P<0.05). |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene