About Enhancer
| Enhancer ID: |
E_02_0143 |
| Species: |
human |
| Position :
|
chr7:100717697-100719697
  |
| Biosample name: |
|
| Experiment class :
|
High+Lowthroughput |
| Enhancer type: |
Enhancer |
| Disease: |
Vascular calcification |
| Pubmed ID: |
31689455
|
| Enhancer experiment: |
Western blot,PCR |
| Enhancer experiment description: |
EPO prevented the reduction of VSMC phenotypic markers, and reversed the increased calcium content and calcium salt deposition in the aortas of CKD rats and cultured calcified VSMCs. |
About Target gene
| Target gene : |
EPO(Epo),EPOR |
| Strong evidence: |
qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: |
RNA-Seq |
| Target gene experiment description: |
EPO prevented the reduction of VSMC phenotypic markers, and reversed the increased calcium content and calcium salt deposition in the aortas of CKD rats and cultured calcified VSMCs.;The EPO receptor (EPOR) mediates the pleiotropic effects of EPO in target cells |
About TF
| TF name : |
-- |
| TF experiment: |
Western blot,PCR |
| TF experiment description: |
EPO prevented the reduction of VSMC phenotypic markers, and reversed the increased calcium content and calcium salt deposition in the aortas of CKD rats and cultured calcified VSMCs.;The EPO receptor (EPOR) mediates the pleiotropic effects of EPO in target cells |
About Function
| Enhancer function : |
EPO prevented the reduction of VSMC phenotypic markers, and reversed the increased calcium content and calcium salt deposition in the aortas of CKD rats and cultured calcified VSMCs. |
| Enhancer function experiment: |
Immunohistochemical staining |
Enhancer function
experiment description: |
EPO prevented the reduction of VSMC phenotypic markers, and reversed the increased calcium content and calcium salt deposition in the aortas of CKD rats and cultured calcified VSMCs. |
About SNP
Upstream Pathway Annotation of TF
| GeneName |
Pathway Name |
Source |
Gene Number |
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene
Expression of target genes for the
enhancer
Enhancer associated SNPs