About Enhancer
| Enhancer ID: | E_02_0141 |
| Species: | human |
| Position : | chr12:55964023-55966023   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Myeloid leukemia |
| Pubmed ID: | 31692040 |
| Enhancer experiment: | PCR, Western blot, flow cytometry, immunofluorescence staining |
| Enhancer experiment description: | In this study, we show that cyclin?dependent kinase 2 (CDK2) negatively regulates C/EBP? protein levels in myeloid leukemia cells |
About Target gene
| Target gene : | CDK2,CEBPA(C/ebpalpha,CBF-A,Cebp) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | In this study, we show that cyclin?dependent kinase 2 (CDK2) negatively regulates C/EBP? protein levels in myeloid leukemia cells;Condi_x0002_tional disruption of CEBPA leads to differentiation block(transition from common myeloid to granulocyte mono_x0002_cyte progenitors), granulopoiesis in particular. |
About TF
| TF name : | -- |
| TF experiment: | PCR,Western blot,Flow cytometry,?????? |
| TF experiment description: | In this study, we show that cyclin?dependent kinase 2 (CDK2) negatively regulates C/EBP? protein levels in myeloid leukemia cells;Condi_x0002_tional disruption of CEBPA leads to differentiation block(transition from common myeloid to granulocyte mono_x0002_cyte progenitors), granulopoiesis in particular. |
About Function
| Enhancer function : | In this study, we show that cyclin?dependent kinase 2 (CDK2) negatively regulates C/EBP? protein levels in myeloid leukemia cells |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
In this study, we show that cyclin?dependent kinase 2 (CDK2) negatively regulates C/EBP? protein levels in myeloid leukemia cells |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene