About Enhancer
| Enhancer ID: | E_02_0138 |
| Species: | human |
| Position : | chr4:186066778-186068778   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Leukemia |
| Pubmed ID: | 31694243 |
| Enhancer experiment: | PCR,Western blot |
| Enhancer experiment description: | Interestingly, the interaction of OAA with I?B kinase ?/? (IKK?/?) strongly attenuated the production of certain proteins and inflammatory cytokines in the TLR3 signaling pathway, such as nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB?),extracellular regulated kinases (ERK), and p38, in an in vitro model. |
About Target gene
| Target gene : | TLR3 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Interestingly, the interaction of OAA with I?B kinase ?/? (IKK?/?) strongly attenuated the production of certain proteins and inflammatory cytokines in the TLR3 signaling pathway, such as nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB?),extracellular regulated kinases (ERK), and p38, in an in vitro model. |
About TF
| TF name : | -- |
| TF experiment: | PCR,Western blot |
| TF experiment description: | Interestingly, the interaction of OAA with I?B kinase ?/? (IKK?/?) strongly attenuated the production of certain proteins and inflammatory cytokines in the TLR3 signaling pathway, such as nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB?),extracellular regulated kinases (ERK), and p38, in an in vitro model. |
About Function
| Enhancer function : | Interestingly, the interaction of OAA with I?B kinase ?/? (IKK?/?) strongly attenuated the production of certain proteins and inflammatory cytokines in the TLR3 signaling pathway, such as nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB?),extracellular regulated kinases (ERK), and p38, in an in vitro model. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Interestingly, the interaction of OAA with I?B kinase ?/? (IKK?/?) strongly attenuated the production of certain proteins and inflammatory cytokines in the TLR3 signaling pathway, such as nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB?),extracellular regulated kinases (ERK), and p38, in an in vitro model. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene