About Enhancer
| Enhancer ID: | E_02_0124 |
| Species: | human |
| Position : | chr14:54839063-54841063   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 31711897 |
| Enhancer experiment: | PCR,Western blot |
| Enhancer experiment description: | GCH1 feedback regulatory protein (GFRP) inhibits GCH1 activity when BH4 levels increase [14]; dihydropteridin reductase (DHPR) and dihydrofolate reductase (DHFR) ensure the re_x0002_cycling of dihydrobiopterin (BH2) into BH4 [15], BH2 being an oxi_x0002_dized and inactive form of BH4. |
About Target gene
| Target gene : | GCH1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | GCH1 feedback regulatory protein (GFRP) inhibits GCH1 activity when BH4 levels increase [14]; dihydropteridin reductase (DHPR) and dihydrofolate reductase (DHFR) ensure the re_x0002_cycling of dihydrobiopterin (BH2) into BH4 [15], BH2 being an oxi_x0002_dized and inactive form of BH4. |
About TF
| TF name : | -- |
| TF experiment: | PCR,Western blot |
| TF experiment description: | GCH1 feedback regulatory protein (GFRP) inhibits GCH1 activity when BH4 levels increase [14]; dihydropteridin reductase (DHPR) and dihydrofolate reductase (DHFR) ensure the re_x0002_cycling of dihydrobiopterin (BH2) into BH4 [15], BH2 being an oxi_x0002_dized and inactive form of BH4. |
About Function
| Enhancer function : | GCH1 feedback regulatory protein (GFRP) inhibits GCH1 activity when BH4 levels increase [14]; dihydropteridin reductase (DHPR) and dihydrofolate reductase (DHFR) ensure the re_x0002_cycling of dihydrobiopterin (BH2) into BH4 [15], BH2 being an oxi_x0002_dized and inactive form of BH4. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
GCH1 feedback regulatory protein (GFRP) inhibits GCH1 activity when BH4 levels increase [14]; dihydropteridin reductase (DHPR) and dihydrofolate reductase (DHFR) ensure the re_x0002_cycling of dihydrobiopterin (BH2) into BH4 [15], BH2 being an oxi_x0002_dized and inactive form of BH4. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene