About Enhancer
| Enhancer ID: | E_02_0121 |
| Species: | human |
| Position : | chr17:27753488-27755488   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Ischemic disease |
| Pubmed ID: | 31713877 |
| Enhancer experiment: | PCR?Western blot |
| Enhancer experiment description: | Clopidogrel reduced serum TNF and IL?1? release in rats with coronary microembolization and experimental LPS-induced mouse model (25, 26). Sarpogrelate decreased immune cell infiltration and NOS2 and TNF expression in diabetic mice. |
About Target gene
| Target gene : | NOS2(HEP-NOS,INOS,NOSA),NOS3(ECNOS,eNOS) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Clopidogrel reduced serum TNF and IL?1? release in rats with coronary microembolization and experimental LPS-induced mouse model (25, 26). Sarpogrelate decreased immune cell infiltration and NOS2 and TNF expression in diabetic mice.;Clopidogrel reduced serum TNF and IL?1? release in rats with coronary microembolization and experimental LPS-induced mouse model (25, 26). Sarpogrelate decreased immune cell infiltration and NOS3 and TNF expression in diabetic mice. |
About TF
| TF name : | -- |
| TF experiment: | PCR?Western blot |
| TF experiment description: | Clopidogrel reduced serum TNF and IL?1? release in rats with coronary microembolization and experimental LPS-induced mouse model (25, 26). Sarpogrelate decreased immune cell infiltration and NOS2 and TNF expression in diabetic mice.;Clopidogrel reduced serum TNF and IL?1? release in rats with coronary microembolization and experimental LPS-induced mouse model (25, 26). Sarpogrelate decreased immune cell infiltration and NOS3 and TNF expression in diabetic mice. |
About Function
| Enhancer function : | Clopidogrel reduced serum TNF and IL?1? release in rats with coronary microembolization and experimental LPS-induced mouse model (25, 26). Sarpogrelate decreased immune cell infiltration and NOS2 and TNF expression in diabetic mice. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Clopidogrel reduced serum TNF and IL?1? release in rats with coronary microembolization and experimental LPS-induced mouse model (25, 26). Sarpogrelate decreased immune cell infiltration and NOS2 and TNF expression in diabetic mice. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene