About Enhancer
| Enhancer ID: | E_02_0120 |
| Species: | human |
| Position : | chrX:123856867-123858867   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Liver cancer |
| Pubmed ID: | 31714653 |
| Enhancer experiment: | PCR |
| Enhancer experiment description: | In addition, expression of phospho-ERK (p-ERK), NF-?B p65 (Ser536), and tumor progression-associated proteins, such as matrix metallopeptidase 9 (MMP-9), vascular endothelial growth factor (VEGF), X-linked inhibitor of apoptosis protein (XIAP), and CyclinD1 were all significantly decreased by magnolol. |
About Target gene
| Target gene : | XIAP |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | In addition, expression of phospho-ERK (p-ERK), NF-?B p65 (Ser536), and tumor progression-associated proteins, such as matrix metallopeptidase 9 (MMP-9), vascular endothelial growth factor (VEGF), X-linked inhibitor of apoptosis protein (XIAP), and CyclinD1 were all significantly decreased by magnolol. |
About TF
| TF name : | -- |
| TF experiment: | PCR |
| TF experiment description: | In addition, expression of phospho-ERK (p-ERK), NF-?B p65 (Ser536), and tumor progression-associated proteins, such as matrix metallopeptidase 9 (MMP-9), vascular endothelial growth factor (VEGF), X-linked inhibitor of apoptosis protein (XIAP), and CyclinD1 were all significantly decreased by magnolol. |
About Function
| Enhancer function : | In addition, expression of phospho-ERK (p-ERK), NF-?B p65 (Ser536), and tumor progression-associated proteins, such as matrix metallopeptidase 9 (MMP-9), vascular endothelial growth factor (VEGF), X-linked inhibitor of apoptosis protein (XIAP), and CyclinD1 were all significantly decreased by magnolol. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
In addition, expression of phospho-ERK (p-ERK), NF-?B p65 (Ser536), and tumor progression-associated proteins, such as matrix metallopeptidase 9 (MMP-9), vascular endothelial growth factor (VEGF), X-linked inhibitor of apoptosis protein (XIAP), and CyclinD1 were all significantly decreased by magnolol. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene