About Enhancer
| Enhancer ID: | E_02_0064 |
| Species: | human |
| Position : | chr5:129458078-129460078   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Valvular heart disease |
| Pubmed ID: | 31844321 |
| Enhancer experiment: | Immunohistochemistry, immunofluorescence, |
| Enhancer experiment description: | Upregulation of endocardial Krppel-like factor 2 in Adamts19 knockout mice precedes hemodynamic perturbation, showing that a tight balance in the Wnt-Adamts19-Klf2 axis is required for proper valve maturation and maintenance. |
About Target gene
| Target gene : | ADAMTS19 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Upregulation of endocardial Krppel-like factor 2 in Adamts19 knockout mice precedes hemodynamic perturbation, showing that a tight balance in the Wnt-Adamts19-Klf2 axis is required for proper valve maturation and maintenance. |
About TF
| TF name : | -- |
| TF experiment: | ?????????? |
| TF experiment description: | Upregulation of endocardial Krppel-like factor 2 in Adamts19 knockout mice precedes hemodynamic perturbation, showing that a tight balance in the Wnt-Adamts19-Klf2 axis is required for proper valve maturation and maintenance. |
About Function
| Enhancer function : | Upregulation of endocardial Krppel-like factor 2 in Adamts19 knockout mice precedes hemodynamic perturbation, showing that a tight balance in the Wnt-Adamts19-Klf2 axis is required for proper valve maturation and maintenance. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Upregulation of endocardial Krppel-like factor 2 in Adamts19 knockout mice precedes hemodynamic perturbation, showing that a tight balance in the Wnt-Adamts19-Klf2 axis is required for proper valve maturation and maintenance. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene