About Enhancer
| Enhancer ID: | E_02_0062 |
| Species: | human |
| Position : | chr14:53946742-53948742   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | -- |
| Pubmed ID: | 31858612 |
| Enhancer experiment: | Flow cytometry, cell viability assay, oil red O staining, Western blot, RT qPCR |
| Enhancer experiment description: | The expression levels of ALP, runt-related transcription factor 2, bone morphogenetic protein 4, osterix and ?-catenin were significantly increased in GSK-137647A-treated group, while the gene and protein levels of peroxisome proliferator-activated receptor ? and CCAAT/enhancer binding protein ? were significantly reduced. |
About Target gene
| Target gene : | BMP4(Atoh5,Math4B,bHLHa7,ngn3) |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | The expression levels of ALP, runt-related transcription factor 2, bone morphogenetic protein 4, osterix and ?-catenin were significantly increased in GSK-137647A-treated group, while the gene and protein levels of peroxisome proliferator-activated receptor ? and CCAAT/enhancer binding protein ? were significantly reduced. |
About TF
| TF name : | -- |
| TF experiment: | ???????????????O???Western blot?RT-Qpcr |
| TF experiment description: | The expression levels of ALP, runt-related transcription factor 2, bone morphogenetic protein 4, osterix and ?-catenin were significantly increased in GSK-137647A-treated group, while the gene and protein levels of peroxisome proliferator-activated receptor ? and CCAAT/enhancer binding protein ? were significantly reduced. |
About Function
| Enhancer function : | The expression levels of ALP, runt-related transcription factor 2, bone morphogenetic protein 4, osterix and ?-catenin were significantly increased in GSK-137647A-treated group, while the gene and protein levels of peroxisome proliferator-activated receptor ? and CCAAT/enhancer binding protein ? were significantly reduced. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
The expression levels of ALP, runt-related transcription factor 2, bone morphogenetic protein 4, osterix and ?-catenin were significantly increased in GSK-137647A-treated group, while the gene and protein levels of peroxisome proliferator-activated receptor ? and CCAAT/enhancer binding protein ? were significantly reduced. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene