About Enhancer
| Enhancer ID: | E_02_0047 |
| Species: | human |
| Position : | chr1:39078887-39080887   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Osteoblast differentiation |
| Pubmed ID: | 28621459 |
| Enhancer experiment: | Western blot,Real time PCR |
| Enhancer experiment description: | Microtubule actin crosslinking factor 1 (MACF1), a key cytoskeletal linker, has been shown to play key roles in signal transduction and in diverse cellular processes |
About Target gene
| Target gene : | MACF1,LEF1 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Microtubule actin crosslinking factor 1 (MACF1), a key cytoskeletal linker, has been shown to play key roles in signal transduction and in diverse cellular processes;It has been demonstrated that TCF1 but not LEF1 binds directly to Runx2 promoter in MC3T3-E1 cells and that Runx2 is a direct target of ?-catenin/TCF1 for the stimulation of osteoblast differentiation |
About TF
| TF name : | -- |
| TF experiment: | Western blot,Real time PCR |
| TF experiment description: | Microtubule actin crosslinking factor 1 (MACF1), a key cytoskeletal linker, has been shown to play key roles in signal transduction and in diverse cellular processes;It has been demonstrated that TCF1 but not LEF1 binds directly to Runx2 promoter in MC3T3-E1 cells and that Runx2 is a direct target of ?-catenin/TCF1 for the stimulation of osteoblast differentiation |
About Function
| Enhancer function : | Microtubule actin crosslinking factor 1 (MACF1), a key cytoskeletal linker, has been shown to play key roles in signal transduction and in diverse cellular processes |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Microtubule actin crosslinking factor 1 (MACF1), a key cytoskeletal linker, has been shown to play key roles in signal transduction and in diverse cellular processes |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene