About Enhancer
| Enhancer ID: | E_02_0007 |
| Species: | human |
| Position : | chr12:57092345-57094345   |
| Biosample name: | |
| Experiment class : | High+Lowthroughput |
| Enhancer type: | Enhancer |
| Disease: | Inflammatory diseases |
| Pubmed ID: | 29343442 |
| Enhancer experiment: | ATAC-seq, ChIP-seq,GRO-seq,RNA-seq,Western Blot,qPCR,ChIP-qPCR |
| Enhancer experiment description: | Thus, the IL-4-STAT6 signaling pathway establishes an alternative polarization-specific epigenenomic signature resulting in dampened macrophage responsiveness to inflammatory stimuli. |
About Target gene
| Target gene : | STAT6,HDAC3 |
| Strong evidence: | qRT-PCR,qPCR,ChIP,3C |
| Less strong evidence: | RNA-Seq |
| Target gene experiment description: | Thus, the IL-4-STAT6 signaling pathway establishes an alternative polarization-specific epigenenomic signature resulting in dampened macrophage responsiveness to inflammatory stimuli.;The Presence of HDAC3 Is Required for IL-4-STAT6-Mediated Repression on a Subset of Genes |
About TF
| TF name : | -- |
| TF experiment: | ATAC-seq, ChIP-seq,GRO-seq,RNA-seq,Western Blot,qPCR,ChIP-qPCR |
| TF experiment description: | Thus, the IL-4-STAT6 signaling pathway establishes an alternative polarization-specific epigenenomic signature resulting in dampened macrophage responsiveness to inflammatory stimuli.;The Presence of HDAC3 Is Required for IL-4-STAT6-Mediated Repression on a Subset of Genes |
About Function
| Enhancer function : | Thus, the IL-4-STAT6 signaling pathway establishes an alternative polarization-specific epigenenomic signature resulting in dampened macrophage responsiveness to inflammatory stimuli. |
| Enhancer function experiment: | Immunohistochemical staining |
| Enhancer function experiment description: |
Thus, the IL-4-STAT6 signaling pathway establishes an alternative polarization-specific epigenenomic signature resulting in dampened macrophage responsiveness to inflammatory stimuli. |
About SNP
| SNP ID: | -- |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer associated network
The number on yellow line represents the distance between enhancer and
target gene